PKEK even-tone peptide suspension · choose base, strength, and preservation
Tetrapeptide-30 (PKEK), an even-tone tetrapeptide studied for reducing the look of UV- and inflammation-associated pigmentation, is found in TEGO® Pep 4-Even-class actives, though Formulate Labs does not sell these branded products.
Tetrapeptide-30 (PKEK even-tone tetrapeptide) · CAS 1036207-61-0
Tetrapeptide-30 is a synthetic four-amino-acid peptide with the sequence Pro-Lys-Glu-Lys (PKEK). Published keratinocyte and volunteer work reports that PKEK can reduce UVB-stimulated expression of inflammatory cytokines and of POMC, the precursor of α-MSH, with downstream effects on tyrosinase expression and the look of UV-associated pigmentation. Finished-formula use is cosmetic: more even-looking tone and a reduction in the appearance of pigment spots, not treatment of pigmentary disease.
Market context: the cosmetic market features branded actives that use Tetrapeptide-30. Formulate Labs sells only the INCI Tetrapeptide-30 raw material and does not sell those trade-name SKUs. TEGO® Pep 4-Even (Evonik) is a preservative-free glycerin/water solution of Tetrapeptide-30 at approximately 1600 ppm (0.16%) active, the same 1X loading we ship. Supplier and journal work positions PKEK for even-looking tone across Caucasian, Asian, and deeper Fitzpatrick phototypes, often alongside a vitamin C derivative such as sodium ascorbyl phosphate. Other catalog listings sell the same INCI as a powder or custom solution; we do not represent those brands.
We supply Tetrapeptide-30 as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the TEGO Pep 4-Even-equivalent reference of 0.16% (1X) or our 10X lab concentrate at 1.6%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Formulate Labs supplies Tetrapeptide-30 by its INCI name only; any reference to trade names is for market context and does not imply we sell those branded products.
Tetrapeptide-30 (PKEK) is documented in even-tone and pigmentation literature as a tetrapeptide active for brighter-looking, more uniform cosmetic skincare. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Keratinocyte and four vehicle-controlled volunteer studies of PKEK (Pro-Lys-Glu-Lys). Reports reduced UVB-stimulated IL-6, IL-8, TNF-alpha, and POMC expression, plus volunteer gene-expression and pigment-spot fading when PKEK was combined with sodium ascorbyl phosphate.
Double-blind, vehicle-controlled facial study of PKEK in Fitzpatrick V-VI subjects. Expert grading of digital images found the peptide formula superior to vehicle at 12 weeks for overall appearance and evenness of skin tone.
Ex vivo human-skin penetration study of Tetrapeptide-30 (PKEK, CAS 1036207-61-0). Compares a standard cream versus a microemulsion vehicle and discusses how hydrophilic PKEK distributes in stratum corneum versus viable layers.
Peer-reviewed overview of cosmetic peptide classes and evidence standards. Useful context when reviewing even-tone and pigment-modulating peptide actives alongside other topical peptide families.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the TP-30 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
