TP-21 cosmetic peptide suspension · choose base, strength, and preservation
Tetrapeptide-21, a peptide known for significantly boosting extracellular matrix (ECM) formation and outperforming Palmitoyl Pentapeptide-4 in anti-aging efficacy, is found in TEGO® Pep 4-17 MB and SpecPed® SC-Tetra21-class actives, though Formulate Labs does not sell these branded products.
Tetrapeptide-21 (Uplevity / ECM organization mimic) · CAS 959610-30-1
Tetrapeptide-21 is a cutting-edge synthetic peptide renowned for its profound impact on skin's extracellular matrix (ECM) formation. Research demonstrates its significant ability to boost ECM components, even outperforming benchmark ingredients like Palmitoyl Pentapeptide-4 in both in vitro and clinical in vivo trials. This mechanism translates to exceptional cosmetic positioning for improving skin topography, reducing the appearance of wrinkles, and promoting overall dermal structural integrity for a smoother, firmer complexion.
Market context: — The cosmetic market features several branded actives that utilize Tetrapeptide-21, though Formulate Labs sells only the INCI Tetrapeptide-21 raw material and not these specific trade-name SKUs. **TEGO® Pep 4-17 MB** (Evonik) is positioned as a preservative-free, nature-inspired ECM booster with clinically verified superiority over first-generation Matrixyl for smoothing skin topography. **SpecPed® SC-Tetra21** (Spec-Chem Industry) is marketed for minimizing deep periorbital wrinkles and reducing skin roughness, targeting anti-aging. **Tetrapeptide-21** (GetChem) is broadly positioned as an antioxidant and firming active designed to promote structural integrity, hydration, and elasticity in comprehensive anti-aging applications.
Formulate Labs offers Tetrapeptide-21 as a highly effective raw material, fully compatible with common aqueous carriers such as Glycerin/Water and Sea Kelp Bioferment stock suspensions. Our formulations leverage the peptide's water-soluble nature, ensuring ease of incorporation into a wide range of cosmetic products. We recommend standard suspension concentrations for formulators, providing flexible integration for optimal performance in diverse anti-aging and skin-rejuvenating applications.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the UplevityTM-equivalent reference of 0.01% or our 10X lab concentrate at 0.1%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Formulate Labs supplies Tetrapeptide-21 by its INCI name only; any reference to trade names is for market context and does not imply we sell those branded products.
Tetrapeptide-21 (Uplevity) is documented in firming and ECM literature as a tetrapeptide active for jawline, neck, and gravity-positioned cosmetic skincare. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Independent delivery study of tetrapeptide-21 in dermal hydrogel models, reporting sustained release and skin-layer penetration relevant to firming serums.
Fibroblast study reporting ECM gene-expression changes with bioactive peptide treatment, supporting tetrapeptide-21 firming-positioned cosmetic use.
Review of matrikine and ECM-organization signal peptides in neck and firming anti-aging cosmetic formulas.
Peer-reviewed context for firming cosmetic peptides and the evidence standards used when reviewing neck and jawline actives.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the TP-21 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
