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Peer-reviewed reference cited in Deep Research evidence brief.
Polygonum Multiflorum Root Extract · 5% aqueous hydroglycerin stock
fixed 5% hydroglycerin stock of Polygonum Multiflorum Root Extract, rich in polyphenolic stilbenoids like TSG, offers a dual-action botanical active for comprehensive hair and scalp well-aging; known in traditional contexts as Fo-ti or He Shou Wu, we standardize by INCI for transparent and consistent cosmetic performance.
Traditional botanical, modern science for hair & scalp wellness.
Botanical Identity: Polygonum Multiflorum Root Extract is a revered botanical in traditional practices, often recognized by its common names Fo-ti and He Shou Wu. At Formulate Labs, we ensure clarity and precision by offering this ingredient under its standardized INCI name, not by various trade designations or specific supplier SKUs.
Dual mechanism: Polygonum Multiflorum Root Extract supports the hair and scalp through a multi-pathway mechanism. For hair appearance, it helps maintain the anagen (growth) phase of the hair cycle by upregulating β-catenin and sonic hedgehog (Shh) signaling pathways in the follicle. It further supports the growth phase by increasing the anti-apoptotic protein Bcl2 and cosmetically counteracting the miniaturizing effects of dihydrotestosterone (DHT) on the dermal papilla. For hair color, the key bioactive TSG has been shown to support natural pigmentation by stimulating melanogenesis, activating the MC1R/MITF/tyrosinase-signaling pathway critical for melanin synthesis in the hair follicle, addressing the appearance of achromotrichia (graying hair).
Use levels: Our standardized 5% hydroglycerin stock of Polygonum Multiflorum Root Extract is recommended for use between 0.001% and 5.0% in topical cosmetic formulas, offering flexibility for various product concentrations.
Market context: Polygonum Multiflorum Root Extract is competitively positioned as a multi-functional, science-backed botanical active for scalp and hair care. It is marketed as a Traditional Chinese Medicine-inspired botanical alternative to synthetic actives for supporting follicle vitality and managing the appearance of thinning hair. Its key strategic advantage is its dual-action capability, allowing for a simplified "well-aging" claim structure that addresses both hair density and the appearance of premature graying through melanin synthesis support. Premium formulations differentiate by emphasizing safety (emodin-reduced, hepatotoxin-free grades) and leveraging advanced delivery systems.
Pricing context: Public pricing data for standardized, cosmetic-grade liquid extracts remains sparse. While raw, unprocessed bulk powders can range from $18 to $25 per kilogram, purified and TSG-standardized liquid extracts for cosmetic use command a significant premium due to processing and quality control costs. Our pricing reflects the value of a high-quality, standardized hydroglycerin extract, with options ranging from sample sizes to bulk pails.
We ship a fixed 5% extract blend with selectable preservation - ready to meter into water-phase formulas at the use rates in the formulation guide below.*
For clarity and regulatory compliance, Formulate Labs refers to this material by its INCI name, Polygonum Multiflorum Root Extract, rather than common trade names (Fo-ti, He Shou Wu).
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
* Structure/function statements based on published cosmetic in-vitro studies. Not evaluated for, and not intended to, diagnose, treat, cure, or prevent any disease.
Polygonum Multiflorum Root Extract is documented in cosmetic peptide/protein literature. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the hydroglycerin stocks on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the bulk composition as it ships at 5% extract loading. Updates when you change stock type and variant above. Full CAS disclosure is on the SDS/TDS for the selected recipe.
SDS + TDS are issued per base and preservative combination. Links swap when you change selections above. COA is batch-specific and ships with the order.
Statements contained on this page (including any marked with *) have not been evaluated by the U.S. Food and Drug Administration. This product is a cosmetic raw material and is not intended to diagnose, treat, cure, or prevent any disease.