Piper Nigrum Seed Extract

Piper nigrum botanical extract - hydroglycerin stock

Piper nigrum · polar phenolic extract

The extract

Black Pepper extract for cosmetic formulas.

Piper nigrum is the botanical behind Black Pepper. Formulate Labs ships Piper Nigrum Seed Extract. We do not sell supplier-branded SKUs.*

What extracts: The botanical carries polar phenolics and water-soluble fractions. Those fractions support antioxidant and skin-conditioning cosmetic positioning.*

Use levels: Dose 0.5% to 5.0% of this extract stock in finished formulas - 0.5–2.0% for daily moisturizers, 3.0–5.0% for intensive serums.*

Ready to meter into finished formulas at the use rates in the formulation guide below. Selectable preservation on every variant.*

Phenolics

Polar marker fraction

2

Hydroglycerin bases

4

Preservation options

Aqueous

Water-phase compatible

Ingredient deck assessment

What this material is and isn’t.

Botanical

Seed extract; polar phenolics

Aqueous stock

Hydroglycerin carrier; water phase

Cruelty-free

No animal testing in our process

Cosmetic grade

For professional formulation use

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications. Common name (Black Pepper) is cited for formulator context only - our product is the INCI extract in our stock.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01

Order placed

You pick a size and quantity. We confirm specs against your formulation if you have one.

02

Robotic production

Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.

03

Batch QC + COA

Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.

Why formulators reach for it

Science-backed cosmetic positioning.

Polar phenolics*

Polar phenolics and water-soluble fractions from Piper nigrum support antioxidant cosmetic positioning in leave-on decks.

Skin-conditioning appearance*

Botanical glycosides and polar fractions support skin-conditioning and calming appearance language. Cosmetic structure/function only - not a drug claim.

Extractable fractions*

The plant carries polar phenolics, glycosides, and related markers. Those fractions support antioxidant and skin-conditioning cosmetic stories. Lot identity is on the COA.

Black Pepper botanical identity*

Extract of Piper nigrum. We sell the INCI extract in our stock, not a supplier-branded SKU.

* Structure/function statements based on published cosmetic in-vitro studies. Not evaluated for, and not intended to, diagnose, treat, cure, or prevent any disease.

Published research

Peer-reviewed literature for due diligence.

Peer-reviewed literature on Piper Nigrum documents polar phenolics and water-soluble fractions. Papers below are independent botanical context, not a claim that this stock was the test article. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

3 curated references

Clinical, observational, and mechanism literature

2026

Paper

Phytotherapy research : PTR

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3-Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia.

Murillo N, Lasso P, Urueña C et al.

Peer-reviewed record for this botanical. Cosmetic context only - not a claim that our stock was the test article.

DOI PubMed

2026

Paper

Biological trace element research

Retraction Note: Ameliorating Nickel-Induced Stress in Hypophthalmichthys molitrix (Silver Carp) Through Piper nigrum Extract Supplementation.

Shah SMFA, Hussain SM, Ali S et al.

Peer-reviewed record for this botanical. Cosmetic context only - not a claim that our stock was the test article.

DOI PubMed

2026

Paper

Cancer management and research

Piper nigrum L. Extract Modulates Cell Cycle and Promotes Apoptosis-Like Cell Death in BT-474 Breast Cancer Cells with Similar Effects in MCF-7 Cells.

Wiraswati HL, Ramadhanti J, Rohmawaty E et al.

Peer-reviewed record for this botanical. Cosmetic context only - not a claim that our stock was the test article.

DOI PubMed

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the extract stocks on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this hydroglycerin stock.

Bulk composition of this Piper Nigrum Seed Extract hydroglycerin stock. Base carrier components scale when preservative is added. Updates when you change base or preservation above. Full CAS disclosure is on the SDS/TDS for the selected variant (FL-PNS-W1-MBS4-5PCT-001).

Water · 61.642% Propanediol · 25.684% Glycerin · 10.274% Piper Nigrum Seed Extract · 0.4% Linatural™ MBS-4 · 2%

Water

CAS7732-18-5

Solvent

61.642%

Propanediol

CAS504-63-2

Humectant / solubilizer

25.684%

Glycerin

CAS56-81-5

Humectant carrier

10.274%

Piper Nigrum Seed Extract

CASContact for COA

Starting botanical load 2% · modeled extracted solids, not an assay

Active botanical extract (flavonoid- and phenolic-rich)

0.4%

Linatural^™ MBS-4

Multifunctional preservative

2%

Inside Linatural^™ MBS-4

Propanediol

CAS504-63-2

1.7%

Ethylhexylglycerin

CAS70445-33-9

0.2%

Benzoic Acid

CAS65-85-0

0.1%

Formulation guide

Built for chemists who sweat the details.

Typical use rate (this stock)

0.5% – 5.0% of this hydroglycerin stock in finished formula (0.5–2.0% for daily moisturizers, 3.0–5.0% for intensive serums)

pH compatibility

4.5 – 5.1 (stock target; finished-formula pH window 4.5 – 7.0 per stability data)

Solubility

Water-soluble - aqueous phase, hydroglycerin, and propanediol-enhanced bases

Temperature

Moderately stable during emulsification; add during cool-down below 40–45 °C; store bulk cool, dry, and shielded from direct UV

Incompatibilities

Extreme low-pH systems that hydrolyze flavonoid glycosides; high-tannin co-extracts that can precipitate

Pairs well with

Panthenol, ceramides, hyaluronic acid, niacinamide, bisabolol, our Sea Kelp Bioferment, peptides

Self-preserving

Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs

Need something different?

Alternate carriers, bulk sizing, or a regulatory packet - reach out and we’ll quote.

Documentation

SDS + TDS are issued per selected recipe. Links swap when you change selections above. A sample COA shows the standard extract QC panel (pH, organoleptic, TAMC/TYMC). Lot-specific COAs ship with every order.

Safety Data Sheet (SDS)

16-section GHS · aqueous extract stock

Technical Data Sheet (TDS)

Composition, storage, incorporation guidance

Certificate of Analysis (sample)

pH · organoleptic · TAMC < 100 · TYMC < 10 CFU/g

Phytochemistry note

We cook the raw botanical powder into the selected carrier. The botanical carries polar phenolics, flavonoid glycosides, and related extractable fractions. Those markers support antioxidant and skin-conditioning cosmetic stories. This is not a solvent isolate or a standardized marker extract. Lot identity appears on the COA and TDS.

Quality & claims

Quality, process, and what we will (and will not) claim.

This is a ready-to-use cosmetic extract stock, not a finished consumer product and not a standardized marker isolate. We cook the raw botanical powder into the selected hydroglycerin or oil carrier. Aqueous lots are released on pH, organoleptic, TAMC, and TYMC (total counts only). Oil macerates are released on organoleptic only. A sample COA is on this page; the lot-specific COA ships with the order.

Download sample Certificate of Analysis

What we sell

A made-to-order cosmetic extract stock in 1 kg, 5 kg, and 17 kg. Choose aqueous hydroglycerin (base + preservation) or, where offered, an oil macerate. Strength is Standard or Concentrated. We sell the INCI extract in our carrier - not a supplier trade-name SKU and not a finished leave-on product.

How it is made

We cook the raw botanical powder into the selected hydroglycerin or oil carrier on our robotic platform, then fill to order. Aqueous stocks ship preserved at the system you select. Oil macerates ship anhydrous (no water-phase preservative). Extracted solids on the composition bar are modeled from the starting botanical load - they are not an HPLC assay.

Standard extract QC

Organoleptic (all stocks): appearance, odor, consistency
Aqueous only: pH (typical 4.5–5.5 for the selected preservative)
Aqueous only: TAMC < 100 CFU/g and TYMC < 10 CFU/g (total counts; no pathogen panel)
Oil macerates: organoleptic only - no pH, TAMC, or TYMC

Not on the default panel: marker assays, heavy metals, pesticides, residual solvents, or individual pathogen screens. Ask if you need those quoted.

What we can claim

Cosmetic structure/function language only: skin- or hair-conditioning, antioxidant cosmetic stories, and appearance-based well-aging positioning supported by published literature. INCI, composition, SDS/TDS, and a lot COA. Compatible with intended cosmetic use under FDA cosmetic rules and EU 1223/2009 when the finished formula is properly assessed.

What we cannot claim

No disease, treatment, cure, or prevent claims. No ingestible / TCM drug positioning. No guarantee that published pathways will reproduce in your finished formula. Not certified organic, COSMOS, vegan, kosher, halal, or non-GMO unless a separate certificate is issued. We do not sell this as a dietary supplement. We do not name a vendor or country of origin for the incoming powder on this page.

Documents with the order

SDS and TDS for the selected recipe (links above swap with your selection). Sample COA on this page for the standard QC panel. Lot-specific COA ships with every batch. Custom loading, alternate carriers, or a fuller regulatory packet - email materials@formulatelabs.ai.

What exactly ships?

A bulk cosmetic extract stock in 1 kg, 5 kg, or 17 kg. Aqueous lots use Water + Propanediol + Glycerin or classic hydroglycerin, with a selectable preservation system. Oil macerates (where offered) ship in a carrier oil, unpreserved. Botanical INCI is Piper Nigrum Seed Extract. The finished-product INCI is the full selected deck in descending order. We sell the INCI extract in our carrier, not a supplier trade-name SKU.

How is it made?

We start from the raw botanical powder and cook it into the selected hydroglycerin or oil carrier on our robotic platform, then fill to order. Aqueous stocks ship preserved at the system you select. Oil macerates ship anhydrous (no water-phase preservative). Extracted solids on the composition bar are modeled from the starting botanical load - they are not an HPLC marker assay.

What is on the COA?

Aqueous: appearance, odor, consistency, pH, TAMC < 100 CFU/g, TYMC < 10 CFU/g (total counts only - no pathogen panel). Oil: organoleptic only; no pH, TAMC, or TYMC. The sample COA on this page shows representative passing numbers. Your lot COA carries the real lot number and measurements. Marker assays, heavy metals, pesticides, residual solvents, and individual pathogen screens are not on the default panel. Ask if you need those quoted.

Is this a standardized marker isolate?

No. This is a whole-botanical powder extraction into the selected carrier, not a solvent isolate and not a standardized marker extract unless a separate assay is specified and quoted. Composition percentages for extracted solids are modeled from starting botanical load.

Where is the botanical from, and is the stock certified?

Stock is manufactured to order in Fenton, MO. Incoming botanical powder varies by lot. We do not list a vendor or country of origin on this page. The finished extract stock is not certified organic, COSMOS, vegan, kosher, halal, or non-GMO unless a separate certificate is issued. No fragrance is added. Full deck disclosure is on the SDS for the selected recipe.

What can we claim on a finished formula?

Cosmetic structure/function language only: skin- or hair-conditioning, antioxidant cosmetic stories, and appearance-based well-aging positioning. Published literature is due diligence, not finished-product claim substantiation. Do not claim diagnosis, treatment, cure, or prevention of disease. Do not position this as an ingestible, TCM drug, or dietary supplement.

Lead time and shelf life?

Made to order on our robotic platform. Aqueous target shelf life is 12–18 months at room temperature, 18–24 months refrigerated, preservative-dependent. Oil macerates are similar unopened ranges; protect from light and heat. Use-by on the lot COA governs the batch you receive.

Compliance & safety

The fine print, in plain English.

What it’s for

Cosmetic raw material for water-phase skincare - black pepper serums, toners, and leave-on care at the use rates in the formulation guide. Not a finished consumer product.

Claims guidance

Cosmetic structure / function language only. Appropriate positioning includes barrier-support appearance, calming/redness-reduction, and antioxidant cosmetic stories. Do not make therapeutic claims (treats eczema, heals wounds/burns, prescription drug claims). We sell the INCI extract in our stock, not a supplier-branded SKU.

Storage

Store tightly closed, protected from light and heat.
Refrigeration optional for extended shelf life per TDS.
Aqueous botanical - monitor for color shift over time.

Regulatory

Finished-product INCI lists components in descending order per the selected variant deck.
Cosmetic function: skin conditioning agent, antioxidant.
Full blend composition disclosed on SDS/TDS (FL-PNS series).
Compatible with FDA cosmetic regulations and EU 1223/2009 for intended cosmetic use when properly incorporated.

Handling

Water-soluble botanical extract - moderately stable during emulsification; add below 40–45 °C. Avoid extreme low-pH co-formulation with concentrated acids. Store bulk cool, dry, and shielded from direct UV. Patch-test finished formulations per standard cosmetic protocol.

Questions

Documentation, regulatory, or custom sizing - email materials@formulatelabs.ai.

Statements contained on this page (including any marked with *) have not been evaluated by the U.S. Food and Drug Administration. This product is a cosmetic raw material and is not intended to diagnose, treat, cure, or prevent any disease.

Something Exciting is Coming

Everything you need on the technical data sheet.

Black Pepper extract for cosmetic formulas.

What this material is and isn’t.

Built fresh on our robotic platform.

Science-backed cosmetic positioning.

Peer-reviewed literature for due diligence.

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3-Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia.

Retraction Note: Ameliorating Nickel-Induced Stress in Hypophthalmichthys molitrix (Silver Carp) Through Piper nigrum Extract Supplementation.

Piper nigrum L. Extract Modulates Cell Cycle and Promotes Apoptosis-Like Cell Death in BT-474 Breast Cancer Cells with Similar Effects in MCF-7 Cells.

What’s in this hydroglycerin stock.

Built for chemists who sweat the details.

Documentation

Quality, process, and what we will (and will not) claim.

The fine print, in plain English.