PT-8 cosmetic peptide suspension · choose base, strength, and preservation
Palmitoyl Tripeptide-8 is a neurocosmetic biomimetic lipopeptide, found in Neutrazen™-class actives, that targets sensitive, hyper-reactive, and redness-prone skin systems, and Formulate Labs does not sell trademarked products.
Pal-NEP-mimetic tripeptide (Neurophroline) · CAS 959610-30-1
Palmitoyl Tripeptide-8 is a neurocosmetic biomimetic lipopeptide engineered to mimic the natural anti-inflammatory neuropeptide α-melanocyte-stimulating hormone (α-MSH). It functions as a competitive antagonist at the Melanocortin-1 Receptor (MC1-R), effectively reducing pro-inflammatory cytokines like IL-1, IL-8, and TNF-α, while also inhibiting Substance P-induced vasodilation and neurogenic edema. This makes Palmitoyl Tripeptide-8 ideally suited for sensitive, hyper-reactive, and redness-prone skin, including formulations targeting rosacea, providing relief from chemical irritants, UV radiation, and mechanical stressors to restore epidermal sensitivity.
Market context: — Palmitoyl Tripeptide-8 is a key active in the neurocosmetic peptide space, competing with trademarked offerings like Neutrazen™ from Lucas Meyer Cosmetics / Clariant, SpecPed® PT8P from Spec-Chem Industry, and Cosroma® PT-8 from COSROMA. While these products are marketed for their specific benefits in reducing neurogenic inflammation, redness, and sensitization, Formulate Labs supplies the pure INCI ingredient, Palmitoyl Tripeptide-8, and does not sell these trademarked SKUs.
Formulate Labs typically offers Palmitoyl Tripeptide-8 as a 0.1% standard glycerin suspension, providing a convenient and stable format for formulators. This pre-dispersed solution ensures easy integration into cosmetic bases, optimizing the delivery of this sensitive-skin active into a wide range of formulations.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the NeurophrolineTM-equivalent reference of 0.03% or our 10X lab concentrate at 0.3%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Please note that Formulate Labs supplies the pure INCI ingredient, Palmitoyl Tripeptide-8, and does not sell trademarked products or finished cosmetic formulations.
Palmitoyl Tripeptide-8 (Neurophroline) is discussed in neurocosmetic and sensitive-skin literature as a stress-response lipopeptide for calmer-looking, even-toned skin. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Review of synthetic peptides formulated for sensitive and reactive skin, including calming lipopeptides in the Neurophroline class.
Foundational melanocortin-receptor peptide work providing mechanistic context for neuropeptide-mimetic cosmetic calming sequences.
Overview of anti-inflammatory and calming signal peptides in sensitive-skin and redness-positioned cosmetic formulas.
Peer-reviewed summary of neurocosmetic and sensitive-skin peptide categories and cosmetic claim framing.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the PT-8 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
