PT-5 cosmetic peptide suspension · choose base, strength, and preservation
Palmitoyl Tripeptide-5 is a foundational biomimetic lipopeptide, found in Syn®-Coll-class actives (we do not sell Syn®-Coll or other branded ingredients), engineered to rejuvenate skin by boosting collagen and protecting the dermal matrix.
Pal-Lys-Val-Lys (Palmitoyl tripeptide-5 / Syn-Coll) · CAS 623172-56-5
Palmitoyl Tripeptide-5 (Pal-Lys-Val-Lys) is a highly penetrating biomimetic lipopeptide that serves as a foundational active for structural skin rejuvenation. Cosmetically positioned as a dual-action collagen booster, the molecule mimics the endogenous extracellular matrix protein thrombospondin-1 (TSP-1) to activate latent transforming growth factor-β (TGF-β). This activation signals dermal fibroblasts to synthesize types I and III collagen, while concurrently inhibiting matrix metalloproteinases (MMP1 and MMP3) to shield the existing dermal matrix from enzymatic degradation.
Market context: — The B2B landscape for cosmetic peptides features prominent branded offerings like Syn®-Coll (from DSM) and Matrixyl (from Sederma, which uses Palmitoyl Tripeptide-1 as a signal peptide for 'retinol-like' efficacy). Formulate Labs exclusively provides the pure INCI, Palmitoyl Tripeptide-5, ensuring formulators access the precise biomimetic amino-acid sequence and proven bioactive performance without the overhead of branded SKU licensing and associated markups.
Our standard Palmitoyl Tripeptide-5 suspension is meticulously formulated in a hydrating glycerin/water base, designed for optimal dermal delivery and integration into a wide array of cosmetic formulations. This approach ensures formulators receive a high-purity, bioavailable active, enabling the full spectrum of its collagen-boosting and protective benefits, aligning with industry best practices for peptide stability and efficacy.
We supply it at 0.1% standard or 1% lab concentrate in glycerin or Sea Kelp Bioferment carriers.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Formulate Labs supplies the pure INCI, Palmitoyl Tripeptide-5, and does not sell branded ingredients such as Syn®-Coll or Matrixyl.
Palmitoyl Tripeptide-5 (Syn-Coll) is documented as a TGF-beta-activating cosmetic peptide that stimulates procollagen synthesis and supports matrix protection in published peptide reviews. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Clinical review discussing palmitoyl tripeptide-5 (Syn-Coll) TGF-beta activation, collagen-stimulation data, and cosmetic use in anti-aging formulas.
Covers signal peptides that up-regulate procollagen and TIMP expression through TGF-beta / matrikine pathways in topical skincare.
Reference clinical split-face study from the same matrikine peptide research lineage, useful for benchmarking collagen-peptide cosmetic endpoints.
Overview of collagen-targeting cosmetic peptides and the evidence standards formulators use when reviewing anti-aging actives.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the PT-5 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
