PT-38 cosmetic peptide suspension · choose base, strength, and preservation
Palmitoyl Tripeptide-38, a peptide found in Matrixyl synthe'6-class actives, is a comprehensive structural repair active that helps smooth deep expression lines by stimulating dermal matrix components; Formulate Labs supplies Palmitoyl Tripeptide-38 only, we do not sell or represent Matrixyl synthe'6.
Palmitoyl tripeptide-38 (Matrixyl synthe’6 active) · CAS 1447824-23-8
Palmitoyl Tripeptide-38 is an innovative lipopeptide, synthesized by conjugating the matrikine-mimetic tripeptide KMK with palmitic acid, a modification that enables superior stratum corneum penetration. In cosmetic science, it is expertly positioned as a comprehensive structural repair active, stimulating the synthesis of six pivotal dermal matrix components: collagen I, II, and IV, fibronectin, hyaluronic acid, and laminin-5. Its sophisticated mechanism involves mimicking naturally occurring extracellular matrix degradation products, effectively signaling fibroblasts to rebuild the dermal–epidermal junction and visibly smooth deep expression lines from the inside out.
Market context: The peptide is predominantly recognized under the proprietary trade name Matrixyl™ synthe'6™ by Sederma, positioned as an advanced "matrix specialist" compared to older, exclusively collagen-focused peptides. Competitor marketing heavily leverages its multi-pathway targeting—collagen, fibronectin, and hyaluronic acid—to justify premium retail pricing in clinical-grade anti-aging serums for mature skin. Formulate Labs supplies Palmitoyl Tripeptide-38 only, a pure INCI blend, and does not sell or represent Matrixyl™ synthe'6™ or other supplier-branded actives.
Formulate Labs offers Palmitoyl Tripeptide-38 as a high-purity INCI blend suspended in a carrier system of Hydroxypropyl Cyclodextrin, Glycerin, and Water. This optimized suspension is designed for ease of incorporation into a variety of cosmetic formulations, typically recommended for use at 2.0% to 4.0%. Our commitment is to supply the pure active ingredient, ensuring formulators receive a consistent, quality material for their innovative product development.
We supply it at 0.03% standard or 0.3% lab concentrate in glycerin or Sea Kelp Bioferment carriers.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Palmitoyl Tripeptide-38 is the INCI name for this material; trade names like Matrixyl™ synthe'6™ refer to supplier-branded actives, which Formulate Labs does not sell or represent.
Palmitoyl Tripeptide-38 (Matrixyl Synthe'6) has peer-reviewed clinical and matrikine literature on multi-matrix stimulation including collagens, laminin, and hyaluronic acid. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
56-day open-label study of a serum with 5 ppm palmitoyl tripeptide-38 reporting significant improvements in skin roughness, homogeneity, and wrinkle appearance.
Authoritative review of matrikine cosmetic peptides and how multi-matrix signal peptides are evaluated in finished formulas.
Peer-reviewed context for advanced matrikine peptides targeting multiple ECM components in anti-aging skincare.
CIR safety review covering related palmitoyl tripeptide ingredients used in the same cosmetic peptide family.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the PT-38 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
