PP-4 cosmetic peptide suspension · choose base, strength, and preservation
Palmitoyl Pentapeptide-4, the collagen-stimulating signal peptide found in Matrixyl-class actives, offers profound wrinkle reduction and elasticity enhancement; Formulate Labs supplies Palmitoyl Pentapeptide-4 only and does not sell or represent Matrixyl.
Pal-KTTKS (Palmitoyl-Lys-Thr-Thr-Lys-Ser) · CAS 214047-00-4
Palmitoyl Pentapeptide-4 (Pal-KTTKS) is a highly specific signal peptide, enhanced with a palmitic acid chain for superior stratum corneum penetration. As a matrikine, it expertly mimics a subfragment of type I procollagen, signaling dermal fibroblasts to synthesize essential extracellular matrix components including collagen types I, III, and IV, elastin, fibronectin, and glycosaminoglycans. This non-irritating peptide offers a gold-standard alternative to retinoids, delivering profound wrinkle reduction and enhanced elasticity without compromising the skin’s vital barrier.
Market context: Sederma pioneered the peptide market by introducing the original Palmitoyl Pentapeptide-4 under the trade name Matrixyl, establishing it as a foundational collagen-stimulating active. While their proprietary portfolio later evolved to include Matrixyl 3000—a dual-peptide blend excluding Palmitoyl Pentapeptide-4—Formulate Labs exclusively supplies the unbranded, high-purity Palmitoyl Pentapeptide-4 INCI active. We do not sell or represent supplier-branded SKUs, enabling independent manufacturers to achieve identical clinical efficacy without trade-name markups.
Formulate Labs provides Palmitoyl Pentapeptide-4 as a 0.1% standard suspension, conveniently pre-dispersed in our Glycerin/Water or Sea Kelp Bioferment stock carriers. This ready-to-use format simplifies integration into your cosmetic formulations, ensuring optimal peptide integrity. When formulating with 3.0% to 8.0% of our 0.1% suspension, you achieve the clinically proven 3 to 5 ppm final active concentration.
We supply it at 0.05% standard (Matrixyl reference) or 0.5% lab concentrate in glycerin or Sea Kelp Bioferment carriers.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Formulate Labs provides the pure INCI Palmitoyl Pentapeptide-4 active and does not sell or represent supplier-branded trade names such as Matrixyl.
Palmitoyl Pentapeptide-4 (Matrixyl / pal-KTTKS) is one of the best-documented matrikine peptides in cosmetic science, with published clinical split-face data on photoaged skin. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
12-week double-blind split-face study (n = 93) at 3 ppm pal-KTTKS showing significant wrinkle and fine-line improvement versus placebo by instrumental and expert grading.
Seminal matrikine review describing how procollagen-derived signal peptides like pal-KTTKS are studied in cosmetic collagen-support formulas.
Peer-reviewed overview citing Matrixyl clinical work and the difference between cosmetic structure/function and drug claims.
CIR expert-panel safety assessment covering palmitoyl matrikine peptides at typical cosmetic use levels.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the PP-4 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
