PH-12 cosmetic peptide suspension · choose base, strength, and preservation
Palmitoyl Hexapeptide-12: A powerful matrikine peptide that visibly firms, repairs, and fortifies the skin barrier by stimulating essential extracellular matrix components.
Palmitoyl hexapeptide-12 (supplier proprietary) · CAS 171263-26-6
Palmitoyl Hexapeptide-12 is a synthetically engineered lipopeptide, strategically designed by combining the elastin-derived "spring fragment" (Val-Gly-Val-Ala-Pro-Gly) with a palmitic acid moiety. This unique structure significantly enhances its stratum corneum penetration and overall bioavailability within the skin [cite: 1, 2]. Positioned in the cosmetic sector as a high-performance firming, restructuring, and barrier-repair active, Palmitoyl Hexapeptide-12 functions primarily as a matrikine signal peptide [cite: 3, 4]. By down-regulating the pro-inflammatory cytokine IL-6, it actively mitigates extracellular matrix degradation while simultaneously stimulating dermal fibroblasts to synthesize new collagen, elastin, fibronectin, and glycosaminoglycans. This makes the peptide highly effective for anti-aging, photo-damage repair, and long-term skin barrier fortification [cite: 3, 7].
Market context: Palmitoyl Hexapeptide-12 is a key active found in premium anti-aging and barrier-repair formulations, including well-known competitor products like Biopeptide EL™ and Dermaxyl™ (both from Sederma/Croda), and SpecPed® POP (Spec-Chem). These competitor offerings are marketed for restoring dermal elasticity, tone, cellular communication, and providing intensive hydration with barrier replenishment. Formulate Labs provides the generic Palmitoyl Hexapeptide-12 INCI material, not these aforementioned proprietary trade-name SKUs.
Our Palmitoyl Hexapeptide-12 is supplied as a standard 0.1% glycerin suspension, designed for seamless integration into your cosmetic formulations while ensuring optimal stability and bioavailability. This ready-to-use format simplifies compounding, allowing formulators to easily achieve desired active concentrations for high-performance skincare applications.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the supplier reference of 0.01% or our 10X lab concentrate at 0.1%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Formulate Labs supplies the generic Palmitoyl Hexapeptide-12 INCI material only, not the aforementioned proprietary trade-name SKUs.
Palmitoyl Hexapeptide-12 appears in peer-reviewed cosmetic literature for dual hair and skin applications, with recent work on skin-layer delivery and tolerability. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Independent study tracking palmitoyl hexapeptide-12 penetration and mechanical interaction with skin components, supporting its cosmetic hair-and-skin positioning.
Dedicated CIR expert-panel safety assessment explicitly covering hexapeptide-12 and its palmitoyl derivative at cosmetic use levels.
Randomized hair-science study of cosmetic peptide actives reporting follicle-anchoring endpoints relevant to hair-care peptide positioning.
Overview of how lipopeptide signal sequences are studied in cosmetic hair-care and skincare finished products.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the PH-12 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
