Palmitoyl Hexapeptide-12

Palmitoyl-Val-Gly-Val-Ala-Pro-Gly · CAS 171263-26-6

The peptide

Palmitoyl Hexapeptide-12 is a synthetic lipopeptide. PubChem CID 10212452 records it as palmitoyl-Val-Gly-Val-Ala-Pro-Gly, molecular formula C38H68N6O8, molecular weight 737.0 g/mol, and CAS 171263-26-6. The hexapeptide sequence Val-Gly-Val-Ala-Pro-Gly is a repeating fragment of elastin. Senior, Griffin, Mecham, Wrenn, Prasad, and Urry reported biological activity of that fragment in the Journal of Cell Biology in 1984. Their paper is about the unmodified hexapeptide, not a clinical study of the palmitoylated cosmetic ingredient.

Formulate Labs supplies Palmitoyl Hexapeptide-12 as a cosmetic raw material in 35% glycerin/water or Sea Kelp Bioferment. It is not Palmitoyl Dipeptide-10, and it is not a drug. Finished-product claims have to be substantiated by the brand.

Identity source: PubChem CID 10212452. Elastin-fragment paper: Senior et al., Journal of Cell Biology, 1984.

737.0

g/mol (PubChem CID 10212452)

6

residues, palmitoyl-VGVAPG

C38

H68N6O8

2

carrier options on this page

Ingredient deck assessment

What this material is and isn’t.

Vegan

Synthetic peptide, no animal-derived inputs

Non-GMO

Solid-phase synthesis, not biotech-derived

Cruelty-free

No animal testing in our process

Kosher-suitable

Ingredient deck assessed Kosher-suitable

Halal-suitable

Ingredient deck assessed Halal-suitable

Made & Mixed in USA

US peptide synthesis + US factory

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01

Order placed

You pick a size and quantity. We confirm specs against your formulation if you have one.

02

Robotic production

Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.

03

Batch QC + COA

Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.

Why formulators reach for it

A peptide with a long cosmetic-science track record.

Recorded hexapeptide identity

PubChem CID 10212452 lists palmitoyl-Val-Gly-Val-Ala-Pro-Gly, CAS 171263-26-6, formula C38H68N6O8, 737.0 g/mol.

Elastin-fragment literature

Senior and colleagues, Journal of Cell Biology, 1984, reported biological activity of the repeating elastin peptide Val-Gly-Val-Ala-Pro-Gly. That paper is about the hexapeptide fragment, not a clinical trial of this suspension.

Supplied as a suspension

Aqueous glycerin/water or Sea Kelp Bioferment, at the strengths listed on this page.

Cosmetic raw material

For formulation into finished topical products. It is not a drug. Finished-product claims have to be substantiated by the brand.

Formulate Labs supplies the generic Palmitoyl Hexapeptide-12 INCI material only, not the aforementioned proprietary trade-name SKUs.

Published research

Peer-reviewed literature for due diligence.

The VGVAPG elastin sequence was reported by Senior and colleagues in the Journal of Cell Biology in 1984. PubChem CID 10212452 identifies Palmitoyl Hexapeptide-12 as the palmitoylated form of that sequence, 737.0 g/mol. Papers below should be read for which material they tested. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

5 curated references

Mechanism, clinical, in-vitro, and review literature

1984

Primary paper

Journal of Cell Biology

Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes

Senior RM, Griffin GL, Mecham RP, Wrenn DS, Prasad KU, Urry DW

Reports biological activity of the elastin hexapeptide VGVAPG. Palmitoyl Hexapeptide-12 is the palmitoylated form of that sequence. This 1984 paper is not a clinical study of the palmitoylated cosmetic ingredient.

DOI PubMed

2025

In vitro

ACS Applied Bio Materials

Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits

Chen Y, et al.

Independent study tracking palmitoyl hexapeptide-12 penetration and mechanical interaction with skin components, supporting its cosmetic hair-and-skin positioning.

DOI PubMed

2018

Review

International Journal of Toxicology

Safety assessment of tripeptide-1, hexapeptide-12, their metal salts and fatty acyl derivatives, and palmitoyl tetrapeptide-7 as used in cosmetics

Johnson W Jr, et al.

Dedicated CIR expert-panel safety assessment explicitly covering hexapeptide-12 and its palmitoyl derivative at cosmetic use levels.

DOI

2013

Clinical trial

Journal of Cosmetic Science

A new strategy to modulate alopecia using a combination of two specific and unique ingredients

Loing E, et al.

Randomized hair-science study of cosmetic peptide actives reporting follicle-anchoring endpoints relevant to hair-care peptide positioning.

PubMed

2009

Review

International Journal of Cosmetic Science

Role of topical peptides in preventing or treating aged skin

Lintner K, et al.

Overview of how lipopeptide signal sequences are studied in cosmetic hair-care and skincare finished products.

DOI PubMed

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this suspension.

This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the PH-12 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.

Glycerin · 35% Palmitoyl Hexapeptide-12 · 0.01% Linatural™ MBS-4 · 2% Water · 62.99%

Glycerin

CAS56-81-5

Humectant carrier

35%

Palmitoyl Hexapeptide-12

CAS171263-26-6

Active peptide

0.01%

Linatural^™ MBS-4

Multifunctional preservative

2%

Inside Linatural^™ MBS-4

Propanediol

CAS504-63-2

1.7%

Ethylhexylglycerin

CAS70445-33-9

0.2%

Benzoic Acid

CAS65-85-0

0.1%

Water

CAS7732-18-5

Solvent (balance)

62.99%

Formulation guide

Built for chemists who sweat the details.

Typical use rate

5% of the 0.01% (1X) suspension (industry recommended); 0.5% of the 0.1% (10X) lab concentrate for the same in-formula peptide level of approximately 0.0005%

Solubility

Fully water-soluble in commercial blends; raw pure powder is water-insoluble and requires solvents like DMSO.

pH compatibility

Optimal structural stability is maintained strictly between pH 4.5 and 6.5.

Add at

Thermally sensitive; must be incorporated during the cool-down phase (below 40°C).

Mixing

Standard mixing during the cool-down phase (below 40°C) is suitable for incorporation.

Avoid

Degrades rapidly below pH 4.0 and is structurally incompatible with high-concentration AHAs or strong chemical exfoliants.

Pairs well with

No specific incompatibilities beyond pH and strong exfoliants are noted, allowing versatile pairing with a wide range of cosmetic ingredients and other complementary actives. The report does not provide specific peptide pairing recommendations by INCI.

Self-preserving

Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs

Documentation

SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.

Safety Data Sheet (SDS)

16-section GHS · Rev. 0.1 · per-recipe

Technical Data Sheet (TDS)

Composition, attributes, formulation guidance · Rev. 0.1

Need something different?

Custom concentrations, an alternative carrier, allergen-free preservation, COA-on-file, or a regulatory packet for a specific market - reach out and we’ll quote.

Compliance & safety

The fine print, in plain English.

What it’s for

Cosmetic raw material - leave-on hair-care formulations (scalp serums, hair tonics, leave-on hair lotions, density-positioned conditioning treatments) at the use rates above; also acceptable in rinse-off cosmetic products and skincare formats where a peptide-based "supports the look of fuller hair" / scalp-comfort positioning is intended. Not a finished consumer product; not for ingestion, injection, or unsupervised topical use outside a formulated finished product.

Claims guidance

Cosmetic structure / function language only (e.g. supports the appearance of fuller-looking hair, supports a smoother-looking finish). Avoid hair-growth drug language (“regrows hair”, “treats alopecia”). Do not make therapeutic claims. The peptide is studied in cosmetic in-vitro and panel work; downstream finished-product claims must be substantiated by the brand.

Storage

Store between 2-25 °C in original sealed container away from direct light.
Cold storage extends shelf life by ~50% relative to room temperature.
Once opened, use within the period stated on the COA.

Regulatory

INCI: Palmitoyl Hexapeptide-12 (per ICID and PCPC dictionary).
Not classified as hazardous based on currently available information per OSHA HazCom 2012 / GHS.
Compatible with FDA cosmetic regulations and EU 1223/2009 for the intended use.
SDS section 16 disclaimer applies; see the per-recipe SDS for the full classification.

Sensitivity

Palmitoyl Hexapeptide-12 is generally well-tolerated in cosmetic use at the rates above; the supplier’s HET-CAM and AMES studies on the peptide indicate non-irritating and non-mutagenic behavior at industry-standard concentrations. The peptide is light-sensitive: store and ship in opaque containers, and avoid prolonged exposure to direct sunlight in finished formulations. Avoid prolonged contact with strong oxidisers, sulfuric or phosphoric acids, acetic anhydride, sustained heat above 45 °C, and prolonged exposure to pH > 7.0 - any of these can hydrolyze the peptide and reduce in-formula activity. Patch-test finished formulations per standard cosmetic protocol.

Questions

Documentation, regulatory, custom recipes, COA-on-file requests, or anything else - email materials@formulatelabs.ai and we’ll route to the right person.

Something Exciting is Coming

Palmitoyl Hexapeptide-12

Everything you need on the technical data sheet.