SYN-TACKS™ sister lipopeptide (Palm-Lys-Val-Dab) · choose base, strength, and preservation
Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, a high-performance signal peptide/protein found in Matrixyl synthe'6-class actives, effectively targets the dermal-epidermal junction to enhance skin compactness and reduce deep expression lines; Formulate Labs supplies Palmitoyl Dipeptide-5 Diaminohydroxybutyrate only and does not sell or represent Matrixyl synthe'6 fragment.
Pal-Dab-OH (Matrixyl synthe’6 co-active fragment) · CAS 959610-54-9
Palmitoyl Dipeptide-5 Diaminohydroxybutyrate is an amphiphilic signal peptide expertly engineered to penetrate the stratum corneum and specifically target the dermal-epidermal junction (DEJ). This molecule works by signaling fibroblasts to boost the synthesis of crucial structural DEJ proteins, including Laminin V, Integrin β4, and Collagens IV, VII, and XVII. This comprehensive stimulation directly counteracts the age-related flattening of the DEJ, thereby improving intercellular communication and nutrient exchange within the skin. Clinically, this mechanism supports its role as a powerful active for enhancing cutaneous compactness, restoring elasticity, and significantly reducing the appearance of deep expression lines.
Market context: Competitors often market Palmitoyl Dipeptide-5 Diaminohydroxybutyrate combined with Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine under proprietary trade names such as SYN®-TACKS, positioning them as premium actives for mature skin and DEJ-rebuilding. Commercial formulators leverage this ingredient's clinical claims for high-end anti-aging serums and barrier repair treatments, focusing on cellular cohesion, wrinkle reduction, and structural dermal support. Formulate Labs strictly supplies the unbranded INCI raw material, ensuring B2B formulators access the active Palmitoyl Dipeptide-5 Diaminohydroxybutyrate chemistry directly, independent of specific competitor trade-name SKUs or proprietary supplier blends.
Formulate Labs offers Palmitoyl Dipeptide-5 Diaminohydroxybutyrate as a stable, ready-to-use 0.1% glycerin suspension, providing formulators with a cost-effective and convenient way to incorporate this powerful peptide into their advanced cosmetic formulations. While the pure active peptide is functional at parts-per-million (ppm) levels, our standardized suspension simplifies integration, allowing for precise dosing and consistent performance across a range of high-performance skincare applications.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the Matrixyl synthe’6-fragment reference of 0.001% or our 10X lab concentrate at 0.01%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
The INCI name Palmitoyl Dipeptide-5 Diaminohydroxybutyrate refers to the pure chemical active ingredient; trade names such as Matrixyl synthe'6 fragment refer to supplier-branded actives that Formulate Labs does not sell or represent.
Palmitoyl Dipeptide-5 Diaminohydroxybutyrate is a Matrixyl synthe'6 co-active lipopeptide fragment with published multi-matrix matrikine clinical and safety literature. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
56-day clinical study of Matrixyl synthe'6 co-actives reporting significant improvements in skin roughness, homogeneity, and wrinkle appearance.
Foundational matrikine review describing how Matrixyl synthe'6 lipopeptide fragments are studied in multi-peptide anti-aging systems.
Landmark Sederma matrikine split-face study providing clinical benchmarking context for Matrixyl synthe'6-family peptide formulas.
CIR safety review covering related palmitoyl matrikine lipopeptides at cosmetic concentrations.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the PD-5H loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
