NPT-56 cosmetic peptide suspension · choose base, strength, and preservation
N-Prolyl Palmitoyl Tripeptide-56 Acetate is an advanced synthetic matrikine lipopeptide designed to target and reduce vertical expression lines by reconstructing dermal morphology.
N-Prolyl-Palmitoyl tripeptide-56 acetate (supplier proprietary) · CAS 1899049-18-3
N-Prolyl Palmitoyl Tripeptide-56 Acetate is an advanced synthetic matrikine lipopeptide that upregulates longevity pathways to re-establish critical connections between the fibroblast nucleus and the extracellular matrix. This action stimulates the synthesis of Collagen I, III, IV, VI, and fibronectin, enabling it to reconstruct dermal morphology from the inside out. In cosmetic applications, it is uniquely positioned to target the reduction of “sad” vertical expression lines—such as frown lines, marionette lines, and nasogenian folds—as well as crow’s feet.
Market context: — N-Prolyl Palmitoyl Tripeptide-56 Acetate is predominantly recognized as the peptide found in Matrixyl® Morphomics™-class actives. It is positioned to compete with, or complement, other matrikine-class peptides like those found in Matrixyl 3000 and Matrixyl Synthe’6-class actives, by differentiating itself through highly targeted action on vertical expression lines and dermal connectivity, rather than generalized skin elasticity. Formulate Labs supplies the generic INCI N-Prolyl Palmitoyl Tripeptide-56 Acetate only and does not sell trade-name SKUs.
We supply it at 0.02% standard or 0.2% lab concentrate in glycerin or Sea Kelp Bioferment carriers.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
N-Prolyl Palmitoyl Tripeptide-56 Acetate is the INCI name for this peptide; Formulate Labs supplies only the generic INCI and does not sell trade-name SKUs.
N-Prolyl Palmitoyl Tripeptide-56 Acetate (Matrixyl Morphomics) has peer-reviewed in-vitro and clinical publications on ECM architecture, longevity-gene modulation, and oxidative stress. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Sederma screening study identifying the PP56 sequence and reporting up-regulation of collagen IV/VI, fibronectin, and FOXO-linked longevity pathways in fibroblast models.
Independent formulation study of PP56 in topical emulsions, evaluating antioxidant activity, stability, and in-vitro skin diffusion of the peptide complex.
Context for matrikine-derived cosmetic peptides and how ECM-focused actives are positioned in anti-aging skincare research.
CIR expert-panel safety review covering palmitoyl tripeptide-1 and related matrikine lipopeptides used in cosmetic formulations.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the NPT-56 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
