1995
Mechanism
Cell Biology International
Keratinocyte growth factor
Establishes keratinocyte growth factor as a highly specific mitogen stimulating epithelial cell proliferation during tissue repair.
Recombinant sh-Polypeptide-3 (FGF-7 / KGF)
Recombinant KGF / FGF-7 (sh-Polypeptide-3) in a stabilizing aqueous suspension for barrier-support cosmetic formulas.*
Suspension stabilizers in the shipped bulk are processing aids and are not declared on the finished-product INCI when the material is used as directed. See SDS for details.
sh-Polypeptide-3 · CAS 126469-10-1 · ~19 kDa
sh-Polypeptide-3 is a synthetic recombinant protein analogous to human Keratinocyte Growth Factor (FGF-7). Its mechanism involves specific binding to FGFR2b receptors on epithelial cells, initiating signaling cascades that vigorously stimulate keratinocyte proliferation, enhance dermal cell adhesion, and promote vital collagen synthesis. In cosmetic applications, sh-Polypeptide-3 is strategically positioned as an advanced regenerative active, designed to significantly accelerate anti-aging processes, repair compromised skin barriers, and revitalize hair follicles for improved density.
Market context: The competitive landscape for growth-factor-like actives features prominently with ingredients such as Caregen's CG-KGF, Barentz's KGF, and BIOEFFECT's Barley sh-Polypeptide-3. These offerings are generally positioned for intensive wrinkle reduction, hair loss prevention, and luxury skin barrier repair. Formulate Labs supplies sh-Polypeptide-3 as a pure INCI, distinct from these specific trade-name formulations, offering formulators the foundational active for their unique product innovations.
Formulate Labs provides sh-Polypeptide-3 as a high-purity isolate, allowing formulators maximum flexibility in their product development. While typical pure polypeptide isolate use levels range from 0.05% to 0.2%, this active is often incorporated into finished formulations as part of self-made pre-dispersed aqueous suspensions or 10X lab concentrates, which formulators then use at inputs ranging from 2.5% to 10% for optimal efficacy. This enables precise integration into a diverse range of cosmetic leave-on skin and scalp care applications.
We ship recombinant KGF in a stabilizing aqueous suspension at two strengths — standard (0.08%) for typical cosmetic dilution workflows, or a 10X lab concentrate (0.8%) when you want maximum loading in minimal volume. The suspension helps protect the active during refrigerated storage and reduce deterioration — see SDS for composition details.*
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications. If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
sh-Polypeptide-3 is the International Nomenclature of Cosmetic Ingredients (INCI) name for the specific protein Formulate Labs supplies, and it is distinct from any proprietary trade-name products marketed by other companies.
Keratinocyte Growth Factor / FGF-7 (sh-Polypeptide-3) appears in keratinocyte biology and barrier-renewal literature relevant to cosmetic barrier-support serums. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Establishes keratinocyte growth factor as a highly specific mitogen stimulating epithelial cell proliferation during tissue repair.
Demonstrates that recombinant keratinocyte growth factor drives proliferation and viability of normal human keratinocytes in vitro.
Confirms through clinical review that topically applied growth factors including keratinocyte growth factor enhance extracellular matrix production and skin rejuvenation.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the bulk composition as it ships. Updates dynamically when you change the strength above. The active line shows the KGF loading at the selected concentration. Suspension stabilizers in the shipped bulk protect the active during storage and are not declared on the finished-product cosmetic INCI when the protein is reconstituted / diluted into your formula as directed. Full stabilizer identity and concentration are on the SDS.
SDS + TDS are issued per strength. Links swap when you change concentration above. COA is batch-specific and ships with the order.
Statements contained on this page (including any marked with *) have not been evaluated by the U.S. Food and Drug Administration. This product is a cosmetic raw material and is not intended to diagnose, treat, cure, or prevent any disease.