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Protein · Stabilizing Suspension · Cosmetic Grade

Honey Bee Defensin-1

Recombinant sr-Honey Bee Defensin-1 · antimicrobial peptide

Bio-identical defensin-class antimicrobial peptide for barrier-support and microbiome-balancing cosmetic formulas — skincare and scalp.*

  • Two strengths: 0.1% standard or 1.0% lab concentrate (10X) · 1 g to 10 g glass vials
  • Stabilizing aqueous suspension · refrigerate 2–8 °C
  • Cosmetic INCI: sr-Honey Bee Defensin-1 only · COA + SDS + TDS per strength
Strength: 0.1% sr-Honey Bee Defensin-1 Full composition
Shipped in a stabilizing aqueous suspension to protect protein integrity and extend shelf life. Refrigerate 2–8 °C; reconstitute/dilute into your finished formula per the formulation guide. See SDS for full composition.
Target pH
5.5 – 7.0
Shelf life (RT · refrigerated)
6–12 mo · 12–24 mo
Cosmetic INCI (finished product)
sr-Honey Bee Defensin-1

Suspension stabilizers in the shipped bulk are processing aids and are not declared on the finished-product INCI when the material is used as directed. See SDS for details.

1
Cold chain
Ship & store 2–8 °C
COA & SDS
Every batch
Cosmetic grade
Recombinant protein
Specifications

Everything you need on the technical data sheet.

INCI Name
sr-Honey Bee Defensin-1
CAS #
Contact for COA
Strengths
0.1% std · 1.0% lc (10X)
Carrier
Aqueous stabilizing suspension
Appearance
Opaque suspension; resuspend before use
pH
5.5 – 7.0
Storage
2–8 °C refrigerated
Shelf Life
6–12 mo RT · 12–24 mo refrigerated
Honey Bee Defensin-1 illustration sr-Honey Bee Defensin-1 · ~5.0 kDa defensin-class AMP
The protein

sr-Honey Bee Defensin-1: Unleashing Advanced Cosmetic Potential

The profound mechanism of action and precise cosmetic positioning for sr-Honey Bee Defensin-1 are extensively outlined within its dedicated evidence brief. This protein is strategically developed for primary application in cosmetic leave-on skin care, offering transformative benefits detailed further in our comprehensive documentation.

Market context: Competitive differentiation and strategic positioning of sr-Honey Bee Defensin-1 within the cosmetic raw material sector are thoroughly addressed in the evidence brief's competitor positioning section. This provides crucial insights into its unique value proposition and how it stands apart from other actives.

Formulate Labs presents sr-Honey Bee Defensin-1 in its standard strength. Specifics regarding our advanced suspension carriers, optimal concentrations, and expert formulation insights are comprehensively covered in the evidence brief, ensuring seamless integration and maximized efficacy in your product development.

We ship recombinant sr-Honey Bee Defensin-1 in a stabilizing aqueous suspension at two strengths — standard (0.1%) for typical cosmetic dilution workflows, or a 10X lab concentrate (1%) when you want maximum loading in minimal volume. The suspension helps protect the active during refrigerated storage; reconstitute per TDS before incorporation.*

MMP-9
Keratinocyte migration pathway
~5 kDa
Defensin-class AMP
Vegan
Bio-identical recombinant
2
Remodeling + antimicrobial paths
Ingredient deck assessment

What this material is and isn’t.

Vegan
Recombinant bio-identical protein — no bee-derived extract inputs
Non-GMO
Bioengineered / fermentation-derived where applicable
Cruelty-free
No animal testing in our process
Kosher-suitable
Ingredient deck assessed Kosher-suitable
Halal-suitable
Ingredient deck assessed Halal-suitable

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications. If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01
Order placed
You pick a size and quantity. We confirm specs against your formulation if you have one.
02
Robotic production
Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.
03
Batch QC + COA
Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.
Why formulators reach for it

Science-backed cosmetic positioning.

sr-Honey Bee Defensin-1 Activity
Specific activity and efficacy data for sr-Honey Bee Defensin-1 are detailed in the evidence brief's mechanism and literature sections.
Cosmetic Positioning with sr-Honey Bee Defensin-1
sr-Honey Bee Defensin-1 is primarily designed for cosmetic leave-on skin care applications, with further specific positioning detailed in the evidence brief.
Formulation Benefits of sr-Honey Bee Defensin-1
Comprehensive formulation guidance, including specific benefits for formulators, is meticulously outlined in the evidence brief formulation guidance section.
Regulatory & Claims for sr-Honey Bee Defensin-1
As a cosmetic raw material, sr-Honey Bee Defensin-1 enables <strong>structure/function claims</strong> on finished products, requiring brand substantiation.

sr-Honey Bee Defensin-1 is our INCI name for this material. No trade or context names are associated with this specific raw material.

Published research

Peer-reviewed literature for due diligence.

Bee defensin-1 (sr-Honey Bee Defensin-1) appears in keratinocyte MMP-9 / re-epithelialization studies and honeybee antimicrobial-peptide literature relevant to cosmetic barrier and microbiome positioning. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

2017
Mechanism
Scientific Reports

Bee-derived antibacterial peptide, defensin-1, promotes wound re-epithelialisation in vitro and in vivo

Bucekova M, et al.

Identifies recombinant bee defensin-1 as the royal-jelly factor that stimulates keratinocyte MMP-9 secretion and migration.

2023
Review
Cosmetics

Applications of Beehive Products for Wound Repair and Skin Care

Ranzato E, et al.

Reviews beehive bioactives including defensin-1 in skin-care and barrier-context literature for formulators evaluating honeybee AMP positioning.

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this suspension.

This is the bulk composition as it ships. Updates dynamically when you change the strength above. The active line shows the sr-Honey Bee Defensin-1 loading at the selected concentration. Suspension stabilizers in the shipped bulk protect the active during storage and are not declared on the finished-product cosmetic INCI when the protein is reconstituted / diluted into your formula as directed. Full stabilizer identity and concentration are on the SDS.

Suspension stabilizer · 35% sr-Honey Bee Defensin-1 · 0.1% Purified Water · 64.9%
Suspension stabilizer
Salting-out stabilizer (see SDS)
35%
sr-Honey Bee Defensin-1
CASContact for COA
Active protein / peptide
0.1%
Purified Water
CAS7732-18-5
Solvent (balance)
64.9%
Formulation guide

Built for chemists who sweat the details.

Typical use rate
Refer to the evidence brief formulation guidance for typical use rates.
Solubility
Refer to the evidence brief formulation guidance for solubility information.
pH compatibility
Refer to the evidence brief formulation guidance for pH compatibility.
Add at
Refer to the evidence brief formulation guidance for recommended addition points.
Mixing
Refer to the evidence brief formulation guidance for mixing instructions.
Avoid
Refer to the evidence brief formulation guidance for substances to avoid.
Pairs well with
Refer to the evidence brief formulation guidance for recommended pairings with other peptides and ingredients.
Preservation
Unpreserved suspension — finished formula must include appropriate preservation

Documentation

SDS + TDS are issued per strength. Links swap when you change concentration above. COA is batch-specific and ships with the order.

Need something different?
Custom concentrations, bulk sizing, COA-on-file, or a regulatory packet - reach out and we’ll quote.
Compliance & safety

The fine print, in plain English.

What it’s for
Cosmetic raw material for leave-on and rinse-off skincare and scalp care at the use rates in the formulation guide — clarifying serums, barrier recovery creams, soothing masks, and microbiome-positioned scalp treatments. Reconstitute / dilute the suspension per TDS before incorporation. Not a finished consumer product.
Claims guidance
Cosmetic structure / function language only. Appropriate positioning includes barrier-support appearance, microbiome-balancing cosmetic antimicrobial benefits, and clarifying / blemish-prone skin appearance. Do not make therapeutic claims (treats acne medically, heals wounds, antibiotic or prescription drug claims). Downstream finished-product claims must be substantiated by the brand.
Storage
  • Store refrigerated at 2–8 °C in original sealed container.
  • Protect from light; do not freeze.
  • Room-temperature excursions shorten shelf life; see TDS for opened-vial guidance.
Regulatory
  • Finished-product INCI: sr-Honey Bee Defensin-1 (suspension processing aids not declared when used as directed).
  • Cosmetic function classes: anti-microbial agent, skin protectant, skin conditioning agent.
  • Full suspension composition, including stabilizer identity, is disclosed on the SDS.
  • Compatible with FDA cosmetic regulations and EU 1223/2009 for the intended use when properly reconstituted.
Handling
Protein suspensions require gentle handling and cold-chain discipline. Reconstitute per TDS; avoid prolonged agitation or heat. Patch-test finished formulations per standard cosmetic protocol.
Questions
Documentation, regulatory, or custom sizing - email materials@formulatelabs.ai.

Statements contained on this page (including any marked with *) have not been evaluated by the U.S. Food and Drug Administration. This product is a cosmetic raw material and is not intended to diagnose, treat, cure, or prevent any disease.

1 g
$280.00
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