Hexanoyl Dipeptide-3 Norleucine Acetate cosmetic peptide suspension · peptide found in PerfectionPeptide P3-class actives™ / biomimetic desquamation peptide · choose base, strength, and preservation
Hexanoyl Dipeptide-3 Norleucine Acetate, the biomimetic peptide found in PerfectionPeptide P3-class actives, offers a gentle yet effective approach to skin renewal; Formulate Labs supplies Hexanoyl Dipeptide-3 Norleucine Acetate only — we do not sell or represent PerfectionPeptide P3.
Hexanoyl-DAP-Nle (PerfectionPeptide P3) · CAS 860627-90-3
Hexanoyl Dipeptide-3 Norleucine Acetate is a synthetic biomimetic tripeptide engineered to accelerate the skin's natural desquamation process. By mimicking the “RAL” (Arg-Ala-Leu) amino acid sequence of desmocollin, the peptide competitively binds to cell adhesion recognition (CAR) sites on corneodesmosomes, disrupting the cadherin bonds between dead keratinocytes in the stratum corneum. Its cosmetic positioning focuses on providing a “smart,” non-irritating peeling effect that speeds cell turnover, refines surface texture, and improves hydration without the barrier damage typically associated with traditional chemical exfoliants.
Market context: The primary commercial benchmark for Hexanoyl Dipeptide-3 Norleucine Acetate is observed in actives like PerfectionPeptide P3, which are marketed as biologically active desquamation reactivators for biomimetic peeling, intense hydration, and wrinkle reduction. Formulate Labs strictly supplies the pure INCI equivalent (Hexanoyl Dipeptide-3 Norleucine Acetate) and does not sell or distribute competitor trade-name SKUs.
Formulate Labs offers Hexanoyl Dipeptide-3 Norleucine Acetate in a convenient 0.1% standard glycerin suspension, providing formulators with an easy-to-incorporate and stable solution for diverse cosmetic applications. This form ensures optimal delivery and efficacy, simplifying your product development process while maintaining the highest standards of quality.
Hair & scalp note: in the skinification-of-hair trend, P3 enables color-safe scalp renewal — pre-shampoo or leave-on scalp serums that clear dead-cell and sebum buildup at neutral pH without stripping hair dye or damaging keratin like salicylic or glycolic scalp acids.*
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Hexanoyl Dipeptide-3 Norleucine Acetate is the INCI name for the active ingredient; trade names such as PerfectionPeptide P3 refer to supplier-branded actives, which Formulate Labs does not sell or represent.
Hexanoyl Dipeptide-3 Norleucine Acetate (PerfectionPeptide P3) is a Mibelle biomimetic desquamation peptide that competitively inhibits the desmoglein–desmocollin corneodesmosome bond — delivering acid-free cellular turnover at physiological pH (Schmid et al., 2008; Mibelle, 2018). These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Details competitive inhibition of the desmoglein–desmocollin complex via a biomimetic CAR sequence — the core mechanism behind PerfectionPeptide P3 physiological peeling.
Technical and clinical efficacy report demonstrating desmoglein mimicry, stratum corneum transit-time reduction, wrinkle-depth improvement, and hydration gains at 1–2% use levels.
Peer-reviewed context for cosmetic peptide actives including resurfacing and renewal-positioned sequences in leave-on skincare.
Clinical review of cosmetic peptide categories including gentle renewal and texture-refining actives suitable for sensitive-skin regimens.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the HD-3N loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
