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Peptide · Aqueous Suspension · Cosmetic Grade

Hexanoyl Dipeptide-3 Norleucine Acetate

HD-3N cosmetic peptide suspension · choose base, strength, and preservation

Hexanoyl Dipeptide-3 Norleucine Acetate is the acetate salt of hexanoyl-Arg-Ala-Nle-NH2 (PubChem CID 71587827, CAS 860627-90-3, formula C23H45N7O6, 515.6 g/mol). Formulate Labs supplies it as a cosmetic raw material in aqueous suspension.

  • Two bases, two strengths, four preservation options - 10 recipes total, all made-to-order
  • Cosmetic-grade Hexanoyl Dipeptide-3 Norleucine Acetate · CAS 860627-90-3 · MW 515.6 g/mol
  • COA + SDS + TDS included with every batch · cold-chain optional on request
Base: Glycerin Suspension
Carrier: our single-origin Sea Kelp Bioferment. View material
Strength: 0.05% HD-3N
Preservation: Linatural™ MBS-4 INCI breakdown
35% glycerin in water. Selectable preservative; broadest compatibility across personal-care formats. Preserved with Linatural™ MBS-4 at 2%.
Target pH
4.5 – 5.1
Shelf life (RT · cold)
12–18 mo · 18–24 mo
Final INCI deck (this suspension, ordered by %)
Water, Glycerin, Propanediol, Ethylhexylglycerin, Benzoic Acid, Hexanoyl Dipeptide-3 Norleucine Acetate
1
Cosmetic grade
Solid-phase synthesis
COA & SDS
Every single batch
Two carriers
Glycerin or bioferment
Specifications

Everything you need on the technical data sheet.

Peptide INCI
Hexanoyl Dipeptide-3 Norleucine Acetate
CAS Number
860627-90-3
Molecular Wt
515.6 g/mol
Appearance
Clear to faintly straw aqueous fluid
pH
4.5 – 5.1
Use Rate
3% (1X)
Add At
Cool-down, ≤ 40 °C
Shelf Life
12–18 mo room temp
18–24 mo refrigerated
Hexanoyl Dipeptide-3 Norleucine Acetate illustration Hexanoyl-Arg-Ala-Nle acetate · CAS 860627-90-3
The peptide

Hexanoyl Dipeptide-3 Norleucine Acetate

Hexanoyl Dipeptide-3 Norleucine Acetate is a synthetic cosmetic peptide salt. PubChem CID 71587827 records it as the acetate of N2-(1-oxohexyl)-L-arginyl-L-alanyl-L-norleucinamide, molecular formula C23H45N7O6, molecular weight 515.6 g/mol, and CAS 860627-90-3. The FDA substance record uses the same CAS and UNII P8A02Z93M6.

Formulate Labs supplies it as a cosmetic raw material for finished topical products, in 35% glycerin/water or Sea Kelp Bioferment. Supplier technical sheets for trade-name blends that use this INCI are supplier literature. They are not independent clinical findings for this suspension.

Identity source: PubChem CID 71587827. Confirm the lot against the certificate of analysis.

515.6
g/mol (PubChem CID 71587827)
C23
H45N7O6, acetate included
CAS
860627-90-3
2
carrier options on this page
Ingredient deck assessment

What this material is and isn’t.

Vegan
Synthetic peptide, no animal-derived inputs
Non-GMO
Solid-phase synthesis, not biotech-derived
Cruelty-free
No animal testing in our process
Kosher-suitable
Ingredient deck assessed Kosher-suitable
Halal-suitable
Ingredient deck assessed Halal-suitable
Made & Mixed in USA
US peptide synthesis + US factory

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01
Order placed
You pick a size and quantity. We confirm specs against your formulation if you have one.
02
Robotic production
Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.
03
Batch QC + COA
Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.
Why formulators reach for it

Physiological peeling at neutral pH with a mapped desmoglein mechanism.

Recorded chemical identity
PubChem CID 71587827 lists the acetate of N2-(1-oxohexyl)-L-arginyl-L-alanyl-L-norleucinamide, CAS 860627-90-3, formula C23H45N7O6, 515.6 g/mol.
Supplied as a suspension
Aqueous glycerin/water or Sea Kelp Bioferment, at the strengths listed on this page.
Cosmetic raw material
For formulation into finished topical products. Supplier technical notes are not independent clinical findings.
Confirm the lot
Match CAS 860627-90-3 and the molecular weight on the certificate of analysis for the lot you receive.

Hexanoyl Dipeptide-3 Norleucine Acetate is the INCI name for the active ingredient; trade names such as PerfectionPeptide P3 refer to supplier-branded actives, which Formulate Labs does not sell or represent.

Published research

Peer-reviewed literature for due diligence.

Chemical identity is PubChem CID 71587827. Supplier technical sheets exist for trade-name blends that use this INCI. Those sheets are supplier literature, not independent clinical studies of this suspension. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

2008
Supplier note
Personal Care Magazine

Biologically active tripeptide designed to stimulate skin desquamation

Schmid D, Schürch C, Zülli F

Supplier-associated technical article. Not an independent clinical study of the suspension sold on this page.

2018
Supplier data
Mibelle Biochemistry

PerfectionPeptide P3: Biologically active tripeptide to reactivate the natural desquamation process of the skin

Mibelle Biochemistry

Supplier product literature for a trade-name blend. Not an independent clinical finding, and not a document we publish as our own.

2017
Review
Journal of Cosmetic Dermatology

Cosmeceuticals: peptides, proteins, and growth factors

Lupo MP, et al.

Peer-reviewed context for cosmetic peptide actives including resurfacing and renewal-positioned sequences in leave-on skincare.

2016
Review
Indian Dermatology Online Journal

Topical peptides as cosmeceuticals

Pai VV, et al.

Clinical review of cosmetic peptide categories including gentle renewal and texture-refining actives suitable for sensitive-skin regimens.

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this suspension.

This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the HD-3N loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.

Glycerin · 35% Hexanoyl Dipeptide-3 Norleucine Acetate · 0.05% Linatural™ MBS-4 · 2% Water · 62.95%
Glycerin
CAS56-81-5
Humectant carrier
35%
Hexanoyl Dipeptide-3 Norleucine Acetate
CAS860627-90-3
Active peptide
0.05%
Linatural™ MBS-4
Multifunctional preservative
2%
Inside Linatural™ MBS-4
Propanediol
CAS504-63-2
1.7%
Ethylhexylglycerin
CAS70445-33-9
0.2%
Benzoic Acid
CAS65-85-0
0.1%
Water
CAS7732-18-5
Solvent (balance)
62.95%
Formulation guide

Built for chemists who sweat the details.

Typical use rate
3% of the 0.05% (1X) suspension (industry recommended); 0.3% of the 0.5% (10X) lab concentrate for the same in-formula peptide level of approximately 0.0015%
Solubility
Water-soluble
pH compatibility
3.5 to 8.0
Add at
Aqueous phase or cool-down phase below 40°C
Mixing
Withstands short-term heat up to 60°C during formulation; optimal long-term storage requires a dark environment maintained between 4°C and 8°C.
Avoid
Anhydrous systems and high electrolyte concentrations
Pairs well with
Pairs well with other actives like Alpha Hydroxy Acids (AHAs) and Beta Hydroxy Acids (BHAs) for enhanced skin renewal benefits.
Self-preserving
Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs

Documentation

SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.

Need something different?
Custom concentrations, an alternative carrier, allergen-free preservation, COA-on-file, or a regulatory packet for a specific market - reach out and we’ll quote.
Compliance & safety

The fine print, in plain English.

What it’s for
Cosmetic raw material for leave-on and rinse-off skincare where acid-free resurfacing, gentle exfoliation, or sensitive-skin renewal positioning is intended (serums, creams, treatment masks). Also for scalp-care pre-shampoo serums and leave-on scalp treatments where color-safe, neutral-pH desquamation is intended — clearing buildup without low-pH acid damage to hair dye or keratin. Not for anhydrous formats. Not a finished consumer product; not for ingestion, injection, or unsupervised topical use outside a formulated finished product.
Claims guidance
Cosmetic structure / function language only (e.g. supports a smoother-looking finish, supports the appearance of refined skin texture, helps clear the look of surface buildup). Avoid chemical peel drug language (“chemical peel,” “treats acne,” “medical exfoliation”). Do not position as a collagen stimulator — mechanism is corneodesmosome-mediated desquamation, not matrix synthesis. Downstream finished-product claims must be substantiated by the brand.
Storage
  • Store between 2-25 °C in original sealed container away from direct light.
  • Cold storage extends shelf life by ~50% relative to room temperature.
  • Once opened, use within the period stated on the COA.
Regulatory
  • INCI: Hexanoyl Dipeptide-3 Norleucine Acetate (per ICID and PCPC dictionary).
  • Not classified as hazardous based on currently available information per OSHA HazCom 2012 / GHS.
  • Compatible with FDA cosmetic regulations and EU 1223/2009 for the intended use.
  • SDS section 16 disclaimer applies; see the per-recipe SDS for the full classification.
Sensitivity
Hexanoyl Dipeptide-3 Norleucine Acetate is generally well-tolerated in cosmetic use at the rates above; the supplier’s HET-CAM and AMES studies on the peptide indicate non-irritating and non-mutagenic behavior at industry-standard concentrations. The peptide is light-sensitive: store and ship in opaque containers, and avoid prolonged exposure to direct sunlight in finished formulations. Avoid prolonged contact with strong oxidisers, sustained heat at or above 40 °C after addition, high-shear processing once incorporated, high electrolyte loads that destabilize liposomes, and anhydrous systems. Patch-test finished formulations per standard cosmetic protocol.
Questions
Documentation, regulatory, custom recipes, COA-on-file requests, or anything else - email materials@formulatelabs.ai and we’ll route to the right person.
1 kg
$400.00
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