Something Exciting is Coming

We're working hard to bring you an amazing new experience. Stay tuned for updates!

Launching 2026
Schedule a Call
Peptide · Aqueous Suspension · Cosmetic Grade

Caprooyl Tetrapeptide-3

CT-3 cosmetic peptide suspension · choose base, strength, and preservation

Caprooyl Tetrapeptide-3 is a caproic-acid lipopeptide sold as a cosmetic raw material. Chemical catalogs list CAS 1012317-71-3 for caprooyl-Lys-Gly-His-Lys (about 565.7 g/mol, free base). A separate PubChem name record describes a different connectivity, so the lot certificate of analysis controls the structure supplied.

  • Two bases, two strengths, four preservation options - 10 recipes total, all made-to-order
  • Cosmetic-grade Caprooyl Tetrapeptide-3 · CAS 1012317-71-3 · MW 565.7 g/mol (catalog free base)
  • COA + SDS + TDS included with every batch · cold-chain optional on request
Base: Glycerin Suspension
Carrier: our single-origin Sea Kelp Bioferment. View material
Strength: 0.05% CT-3
Preservation: Linatural™ MBS-4 INCI breakdown
35% glycerin in water. Selectable preservative; broadest compatibility across personal-care formats. Preserved with Linatural™ MBS-4 at 2%.
Target pH
4.5 – 5.1
Shelf life (RT · cold)
12–18 mo · 18–24 mo
Final INCI deck (this suspension, ordered by %)
Water, Glycerin, Propanediol, Ethylhexylglycerin, Benzoic Acid, Caprooyl Tetrapeptide-3
1
Cosmetic grade
Solid-phase synthesis
COA & SDS
Every single batch
Two carriers
Glycerin or bioferment
Specifications

Everything you need on the technical data sheet.

Peptide INCI
Caprooyl Tetrapeptide-3
CAS Number
1012317-71-3
Molecular Wt
565.7 g/mol (catalog free base)
Appearance
Transparent, colorless aqueous fluid
pH
4.5 – 5.1
Use Rate
3% (1X)
Add At
Cool-down, ≤ 40 °C
Shelf Life
12–18 mo room temp
18–24 mo refrigerated
Caprooyl Tetrapeptide-3 illustration Caprooyl Tetrapeptide-3 · CAS 1012317-71-3
The peptide

Caprooyl Tetrapeptide-3

Caprooyl Tetrapeptide-3 is a caproic-acid (hexanoyl) lipopeptide used as a cosmetic raw material. Public records do not all describe the same connectivity. Chemical catalogs assign CAS 1012317-71-3 to caprooyl-Lys-Gly-His-Lys, formula C26H47N9O5, about 565.7 g/mol for the free base. PubChem CID 71599291, also titled Caprooyl tetrapeptide-3, is formula C24H42N8O7 and 554.6 g/mol, a different structure. This page does not show a structure drawing.

Supplier technical files for the trade name ChroNOline describe a lipopeptide of four amino acids linked to caproic acid, in a glycerin, water, and dextran blend. That is supplier literature, not an independent clinical study. Formulate Labs supplies the INCI as an aqueous suspension in 35% glycerin/water or Sea Kelp Bioferment, at 0.05% or a 0.5% lab concentrate. The lot certificate of analysis controls which structure was supplied.

Catalog identity often cited for the KGHK form: CAS 1012317-71-3. Separate name record: PubChem CID 71599291.

565.7
g/mol, catalog free base of caprooyl-KGHK
554.6
g/mol, PubChem CID 71599291
COA
lot certificate sets the sequence
2
carrier options on this page
Ingredient deck assessment

What this material is and isn’t.

Vegan
Synthetic peptide, no animal-derived inputs
Non-GMO
Solid-phase synthesis, not biotech-derived
Cruelty-free
No animal testing in our process
Kosher-suitable
Ingredient deck assessed Kosher-suitable
Halal-suitable
Ingredient deck assessed Halal-suitable
Made & Mixed in USA
US peptide synthesis + US factory

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01
Order placed
You pick a size and quantity. We confirm specs against your formulation if you have one.
02
Robotic production
Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.
03
Batch QC + COA
Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.
Why formulators reach for it

A peptide with a long cosmetic-science track record.

Two public structure records
CAS 1012317-71-3 is used in chemical catalogs for caprooyl-Lys-Gly-His-Lys, about 565.7 g/mol as the free base. PubChem CID 71599291, also titled Caprooyl tetrapeptide-3, is a different formula, C24H42N8O7, 554.6 g/mol.
Sequence comes from the COA
This page does not display a structure drawing. Match the lot certificate of analysis before citing a sequence.
Supplied as a suspension
Aqueous glycerin/water or Sea Kelp Bioferment, at the strengths listed on this page.
Cosmetic raw material
For formulation into finished topical products. Supplier efficacy claims are not independent clinical findings.

Formulate Labs supplies Caprooyl Tetrapeptide-3 (INCI) only and does not offer competitor trade-name SKUs.

Published research

Peer-reviewed literature for due diligence.

Caprooyl Tetrapeptide-3 (Chronoline) shares the KGHK matrikine core documented in cosmetic literature for dermal-epidermal junction proteins, laminin, and fibronectin support. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

2009
Review
International Journal of Cosmetic Science

Role of topical peptides in preventing or treating aged skin

Lintner K, et al.

Review of matrikine signal peptides that stimulate ECM components at the dermal-epidermal junction, the same cosmetic mechanism class as KGHK-derived peptides.

2013
Clinical trial
Journal of Cosmetic Science

A new strategy to modulate alopecia using a combination of two specific and unique ingredients

Loing E, et al.

Clinical work on the acetylated KGHK tetrapeptide reporting ECM and follicle-anchoring endpoints; relevant mechanistic context for the caprooyl-KGHK Chronoline sequence.

2015
Review
BioMed Research International

GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration

Pickart L, et al.

Covers matrikine biology and GHK-family peptide effects on laminin, fibronectin, and skin matrix remodeling pathways relevant to DEJ-focused cosmetic actives.

2017
Review
Journal of Cosmetic Dermatology

Cosmeceuticals: peptides, proteins, and growth factors

Lupo MP, et al.

Peer-reviewed summary of signal peptides used in anti-aging cosmetic formulas, including matrikine and ECM-support sequences.

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this suspension.

This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the CT-3 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.

Glycerin · 35% Caprooyl Tetrapeptide-3 · 0.05% Linatural™ MBS-4 · 2% Water · 62.95%
Glycerin
CAS56-81-5
Humectant carrier
35%
Caprooyl Tetrapeptide-3
CAS1012317-71-3
Active peptide
0.05%
Linatural™ MBS-4
Multifunctional preservative
2%
Inside Linatural™ MBS-4
Propanediol
CAS504-63-2
1.7%
Ethylhexylglycerin
CAS70445-33-9
0.2%
Benzoic Acid
CAS65-85-0
0.1%
Water
CAS7732-18-5
Solvent (balance)
62.95%
Formulation guide

Built for chemists who sweat the details.

Typical use rate
3% of the 0.05% (1X) suspension (industry recommended); 0.3% of the 0.5% (10X) lab concentrate for the same in-formula peptide level of approximately 0.0015%
Solubility
Highly water-soluble; compatible with aqueous phases including Glycerin/Water and Sea Kelp Bioferment.
pH compatibility
Optimal stability: 4.5–7.0; Functional range: 3.0–8.0.
Add at
During cooling phase, below 40°C.
Mixing
Avoid
Temperatures above 40°C, direct light, strong oxidants, electrophiles, tannins, and pH below 3.0.
Pairs well with
Self-preserving
Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs

Documentation

SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.

Need something different?
Custom concentrations, an alternative carrier, allergen-free preservation, COA-on-file, or a regulatory packet for a specific market - reach out and we’ll quote.
Compliance & safety

The fine print, in plain English.

What it’s for
Cosmetic raw material - leave-on hair-care formulations (scalp serums, hair tonics, leave-on hair lotions, density-positioned conditioning treatments) at the use rates above; also acceptable in rinse-off cosmetic products and skincare formats where a peptide-based "supports the look of fuller hair" / scalp-comfort positioning is intended. Not a finished consumer product; not for ingestion, injection, or unsupervised topical use outside a formulated finished product.
Claims guidance
Cosmetic structure / function language only (e.g. supports a smoother-looking finish, supports a rested-looking appearance, helps skin look more refreshed). Avoid progerin / disease-aging drug language (“reverses aging”, “treats progeria”, “repairs DNA damage”). Do not make therapeutic claims. The peptide is studied in cosmetic in-vitro and panel work; downstream finished-product claims must be substantiated by the brand.
Storage
  • Store between 2-25 °C in original sealed container away from direct light.
  • Cold storage extends shelf life by ~50% relative to room temperature.
  • Once opened, use within the period stated on the COA.
Regulatory
  • INCI: Caprooyl Tetrapeptide-3 (per ICID and PCPC dictionary).
  • Not classified as hazardous based on currently available information per OSHA HazCom 2012 / GHS.
  • Compatible with FDA cosmetic regulations and EU 1223/2009 for the intended use.
  • SDS section 16 disclaimer applies; see the per-recipe SDS for the full classification.
Sensitivity
Caprooyl Tetrapeptide-3 is generally well-tolerated in cosmetic use at the rates above; the supplier’s HET-CAM and AMES studies on the peptide indicate non-irritating and non-mutagenic behavior at industry-standard concentrations. The peptide is light-sensitive: store and ship in opaque containers, and avoid prolonged exposure to direct sunlight in finished formulations. Avoid prolonged contact with strong oxidisers, sulfuric or phosphoric acids, acetic anhydride, sustained heat above 45 °C, and prolonged exposure to pH > 7.0 - any of these can hydrolyze the peptide and reduce in-formula activity. Patch-test finished formulations per standard cosmetic protocol.
Questions
Documentation, regulatory, custom recipes, COA-on-file requests, or anything else - email materials@formulatelabs.ai and we’ll route to the right person.
1 kg
$400.00
Added to cart View cart →