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Botanical Extract · Aqueous Hydroglycerin · Standard or Concentrated

Andrographis Extract

Andrographis Paniculata Extract

Experience the power of Andrographis Paniculata Extract from Formulate Labs, a standard or concentrated hydroglycerin stock standardized for key diterpene lactone actives like andrographolide. Known by traditional names such as King of Bitters, our INCI material offers advanced cosmetic benefits for modern skincare.

  • Standard or concentrated Andrographis Paniculata Extract in Water + Propanediol + Glycerin Extract or Hydroglycerin Extract base
  • Four preservation systems - 8 recipes total, all made-to-order
  • COA + SDS + TDS per base/preservative variant · 1 kg, 5 kg, and 17 kg
Strength: Standard
Base: Water + Propanediol + Glycerin Extract Full composition
Preservation: Linatural™ MBS-4 INCI breakdown
Aqueous stock with water, propanediol, and glycerin carrying the selected extract loading. Balanced humectancy with propanediol solubilization - default for andrographis serums and toners. Preserved with Linatural™ MBS-4 at 2%.
Target pH
4.5 – 5.1
Shelf life (RT · cold)
12–18 mo · 18–24 mo
Final INCI deck (this stock, ordered by %)
Water, Propanediol, Glycerin, Propanediol, Andrographis Paniculata Extract, Ethylhexylglycerin, Benzoic Acid
Size: 1 kg Formulation guide
1
Andrographis
Diterpene Lactone Extract
COA & SDS
Every batch
Cosmetic grade
Aqueous hydroglycerin
Specifications

Everything you need on the technical data sheet.

INCI Name
Andrographis Paniculata Extract
Common names
Kalmegh · King of Bitters
Strength
Standard or concentrated extract in hydroglycerin stock
Solubility
Aqueous / water phase
Appearance
Amber to brown aqueous fluid
pH (bulk material)
4.5 – 5.1
Add at
Cool-down < 40–45 °C
Shelf Life
12–18 mo RT · 18–24 mo refrigerated
andrographis botanical extract - andrographis hydroglycerin stock A plant known for potent botanical actives.
The extract

Unveiling Andrographis Paniculata Extract: A Multifaceted Skin Active

Botanical Identity: Andrographis Paniculata Extract is derived from the *Andrographis paniculata* plant. Trade Names: Known as Kalmegh and King of Bitters, Formulate Labs provides the INCI-specified material, not proprietary supplier SKUs.

Dual mechanism: Andrographolide modulates the brain-skin axis and helps mitigate the visible effects of oxidative stress by activating the Nrf2 signaling pathway, supporting natural antioxidant enzymes (SOD and catalase). Furthermore, it helps soothe the skin by downregulating pro-inflammatory cytokines (TNF-α and IL-6) and targeting cutaneous TRPV3 channels to alleviate feelings of discomfort and pruritus.

Use levels: Formulate Labs supplies this extract as a Standard or Concentrated hydroglycerin stock, recommended for use at 0.5% – 2.0% in formulations.

Market context: Competitors position *Andrographis Paniculata* Extract around several key narratives: 'Neuro-Cosmetic Activation' (connecting internal soothing to external benefits like reduced fatigue and radiance), 'Receptor-Targeted Relief' (linking bitterness to epidermal bitter taste receptor activation for soothing reactive skin), and 'Stem Cell Preservation' (emphasizing protection of epidermal stem cells from UV-induced damage and anti-photoaging).

We ship standard or concentrated extract stock with selectable preservation - ready to meter into finished formulas at the use rates in the formulation guide below.*

2
Standard / concentrated
2
Hydroglycerin bases
4
Preservation options
Aqueous
Water-phase compatible
Ingredient deck assessment

What this material is and isn’t.

Botanical
Leaf/stem extract; pentacyclic triterpene saponins
Aqueous stock
Hydroglycerin carrier; water phase
Cruelty-free
No animal testing in our process
Cosmetic grade
For professional formulation use

Trade names (Kalmegh, King of Bitters) refer to the botanical source, while Formulate Labs supplies the INCI-specified material.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01
Order placed
You pick a size and quantity. We confirm specs against your formulation if you have one.
02
Robotic production
Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.
03
Batch QC + COA
Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.
Why formulators reach for it

Science-backed cosmetic positioning.

Supports Skin's Natural Defenses
Activates the Nrf2 pathway, boosting antioxidant enzymes like SOD &amp; catalase to help protect skin from oxidative stress.
Helps Soothe & Calm Skin
Downregulates pro-inflammatory cytokines (TNF-&alpha;, IL-6) and targets TRPV3 channels to rapidly alleviate feelings of discomfort and pruritus.
Preserves Epidermal Stem Cells*
Shields vital epidermal stem cells from UVB-induced senescence by activating Collagen XVII, helping to maintain skin's foundational resilience.
Reinforces Dermo-Epidermal Junction*
Strengthens the structural integrity of the DEJ by supporting Collagen IV and Laminin synthesis while inhibiting MMP-9.

* Structure/function statements based on published cosmetic in-vitro studies. Not evaluated for, and not intended to, diagnose, treat, cure, or prevent any disease.

Published research

Peer-reviewed literature for due diligence.

Andrographis Paniculata Extract is documented in cosmetic peptide/protein literature. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

-
Review
See PubMed record

See linked PubMed record

See journal record

Peer-reviewed reference cited in Deep Research evidence brief.

DOIPubMed

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the extract stocks on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this hydroglycerin stock.

Bulk composition at the selected Andrographis Paniculata Extract loading. Base carrier components scale proportionally when preservative is added; extract stays at the selected loading. Updates dynamically when you change base or preservation above. Full CAS disclosure is on the SDS/TDS for the selected variant (FL-APE-W1-MBS4-5PCT-001).

Water · 61.137% Propanediol · 25.474% Glycerin · 10.189% Andrographis Paniculata Extract · 1.2% Linatural™ MBS-4 · 2%
Water
CAS7732-18-5
Solvent
61.137%
Propanediol
CAS504-63-2
Humectant / solubilizer
25.474%
Glycerin
CAS56-81-5
Humectant carrier
10.189%
Andrographis Paniculata Extract
CASContact for COA
Starting botanical load 4% · modeled extracted solids, not an assay
Active botanical extract (triterpene-rich)
1.2%
Linatural™ MBS-4
Multifunctional preservative
2%
Inside Linatural™ MBS-4
Propanediol
CAS504-63-2
1.7%
Ethylhexylglycerin
CAS70445-33-9
0.2%
Benzoic Acid
CAS65-85-0
0.1%
Formulation guide

Built for chemists who sweat the details.

Typical use rate (this stock)
0.5% – 2.0%
pH compatibility
4.5 – 5.1 (stock target; finished-formula pH window per stability data)
Solubility
Water-soluble in supplied glycolic bases.
Temperature
Thermosensitive. Add to the formula during the cool-down phase below 40°C.
Incompatibilities
Avoid use in highly acidic formulations (pH < 3.0) and with strong oxidizing agents.
Pairs well with
Self-preserving
Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs
Need something different?
Custom extract loading, alternate carriers, bulk sizing, or a regulatory packet - reach out and we’ll quote.

Documentation

SDS + TDS are issued per selected recipe. Links swap when you change selections above. A sample COA shows the standard extract QC panel (pH, organoleptic, TAMC/TYMC). Lot-specific COAs ship with every order.

Safety Data Sheet (SDS)
16-section GHS · aqueous extract stock
Technical Data Sheet (TDS)
Composition, storage, incorporation guidance
Certificate of Analysis (sample)
pH · organoleptic · TAMC < 100 · TYMC < 10 CFU/g
Phytochemistry note

We cook the raw botanical powder into the selected carrier. The botanical carries polar phenolics, flavonoid glycosides, and related extractable fractions. Those markers support antioxidant and skin-conditioning cosmetic stories. This is not a solvent isolate or a standardized marker extract. Lot identity appears on the COA and TDS.

Quality & claims

Quality, process, and what we will (and will not) claim.

This is a ready-to-use cosmetic extract stock, not a finished consumer product and not a standardized marker isolate. We cook the raw botanical powder into the selected hydroglycerin or oil carrier. Aqueous lots are released on pH, organoleptic, TAMC, and TYMC (total counts only). Oil macerates are released on organoleptic only. A sample COA is on this page; the lot-specific COA ships with the order.

Download sample Certificate of Analysis
What we sell
A made-to-order cosmetic extract stock in 1 kg, 5 kg, and 17 kg. Choose aqueous hydroglycerin (base + preservation) or, where offered, an oil macerate. Strength is Standard or Concentrated. We sell the INCI extract in our carrier - not a supplier trade-name SKU and not a finished leave-on product.
How it is made
We cook the raw botanical powder into the selected hydroglycerin or oil carrier on our robotic platform, then fill to order. Aqueous stocks ship preserved at the system you select. Oil macerates ship anhydrous (no water-phase preservative). Extracted solids on the composition bar are modeled from the starting botanical load - they are not an HPLC assay.
Standard extract QC
  • Organoleptic (all stocks): appearance, odor, consistency
  • Aqueous only: pH (typical 4.5–5.5 for the selected preservative)
  • Aqueous only: TAMC < 100 CFU/g and TYMC < 10 CFU/g (total counts; no pathogen panel)
  • Oil macerates: organoleptic only - no pH, TAMC, or TYMC
Not on the default panel: marker assays, heavy metals, pesticides, residual solvents, or individual pathogen screens. Ask if you need those quoted.
What we can claim
Cosmetic structure/function language only: skin- or hair-conditioning, antioxidant cosmetic stories, and appearance-based well-aging positioning supported by published literature. INCI, composition, SDS/TDS, and a lot COA. Compatible with intended cosmetic use under FDA cosmetic rules and EU 1223/2009 when the finished formula is properly assessed.
What we cannot claim
No disease, treatment, cure, or prevent claims. No ingestible / TCM drug positioning. No guarantee that published pathways will reproduce in your finished formula. Not certified organic, COSMOS, vegan, kosher, halal, or non-GMO unless a separate certificate is issued. We do not sell this as a dietary supplement. We do not name a vendor or country of origin for the incoming powder on this page.
Documents with the order
SDS and TDS for the selected recipe (links above swap with your selection). Sample COA on this page for the standard QC panel. Lot-specific COA ships with every batch. Custom loading, alternate carriers, or a fuller regulatory packet - email materials@formulatelabs.ai.
What exactly ships?
A bulk cosmetic extract stock in 1 kg, 5 kg, or 17 kg. Aqueous lots use Water + Propanediol + Glycerin or classic hydroglycerin, with a selectable preservation system. Oil macerates (where offered) ship in a carrier oil, unpreserved. Botanical INCI is Andrographis Paniculata Extract. The finished-product INCI is the full selected deck in descending order. We sell the INCI extract in our carrier, not a supplier trade-name SKU.
How is it made?
We start from the raw botanical powder and cook it into the selected hydroglycerin or oil carrier on our robotic platform, then fill to order. Aqueous stocks ship preserved at the system you select. Oil macerates ship anhydrous (no water-phase preservative). Extracted solids on the composition bar are modeled from the starting botanical load - they are not an HPLC marker assay.
What is on the COA?
Aqueous: appearance, odor, consistency, pH, TAMC < 100 CFU/g, TYMC < 10 CFU/g (total counts only - no pathogen panel). Oil: organoleptic only; no pH, TAMC, or TYMC. The sample COA on this page shows representative passing numbers. Your lot COA carries the real lot number and measurements. Marker assays, heavy metals, pesticides, residual solvents, and individual pathogen screens are not on the default panel. Ask if you need those quoted.
Is this a standardized marker isolate?
No. This is a whole-botanical powder extraction into the selected carrier, not a solvent isolate and not a standardized marker extract unless a separate assay is specified and quoted. Composition percentages for extracted solids are modeled from starting botanical load.
Where is the botanical from, and is the stock certified?
Stock is manufactured to order in Fenton, MO. Incoming botanical powder varies by lot. We do not list a vendor or country of origin on this page. The finished extract stock is not certified organic, COSMOS, vegan, kosher, halal, or non-GMO unless a separate certificate is issued. No fragrance is added. Full deck disclosure is on the SDS for the selected recipe.
What can we claim on a finished formula?
Cosmetic structure/function language only: skin- or hair-conditioning, antioxidant cosmetic stories, and appearance-based well-aging positioning. Published literature is due diligence, not finished-product claim substantiation. Do not claim diagnosis, treatment, cure, or prevention of disease. Do not position this as an ingestible, TCM drug, or dietary supplement.
Lead time and shelf life?
Made to order on our robotic platform. Aqueous target shelf life is 12–18 months at room temperature, 18–24 months refrigerated, preservative-dependent. Oil macerates are similar unopened ranges; protect from light and heat. Use-by on the lot COA governs the batch you receive.
Compliance & safety

The fine print, in plain English.

What it’s for
Used in cosmetic and personal care products globally, formulators should verify its status for target markets.
Claims guidance
Claims Guidance: Supported by evidence for antioxidant, soothing, and protective benefits. Not for therapeutic or drug claims. This report does not constitute legal or regulatory advice.
Storage
  • Store tightly closed, protected from light and heat.
  • Refrigeration optional for extended shelf life per TDS.
  • Aqueous botanical - monitor for color shift over time.
Regulatory
  • Finished-product INCI lists components in descending order per the selected variant deck.
  • Cosmetic function: skin conditioning agent, antioxidant, soothing agent
  • Full blend composition disclosed on SDS/TDS (FL-APE series).
  • This report does not constitute legal or regulatory advice.
  • Compatible with FDA cosmetic regulations and EU 1223/2009 for intended cosmetic use when properly incorporated.
Handling
As with all botanical extracts, formulators should verify the ingredient's regulatory status and compliance for their specific target markets.
Questions
Documentation, regulatory, or custom sizing - email materials@formulatelabs.ai.

Statements contained on this page (including any marked with *) have not been evaluated by the U.S. Food and Drug Administration. This product is a cosmetic raw material and is not intended to diagnose, treat, cure, or prevent any disease.

1 kg
$150.00
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