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Peptide · Aqueous Suspension · Cosmetic Grade

Acetyl Tetrapeptide-5

AT-5 cosmetic peptide suspension · choose base, strength, and preservation

Information regarding Acetyl Tetrapeptide-5's specific mechanism and hero benefits is not available in the provided research report.

  • Two bases, two strengths, four preservation options - 10 recipes total, all made-to-order
  • Cosmetic-grade Acetyl Tetrapeptide-5 · CAS 928006-50-2 · MW ~492 g/mol (approx.)
  • COA + SDS + TDS included with every batch · cold-chain optional on request
Base: Glycerin Suspension
Carrier: our single-origin Sea Kelp Bioferment. View material
Strength: 0.1% AT-5
Preservation: Linatural MBS-4 INCI breakdown
35% glycerin in water. Selectable preservative; broadest compatibility across personal-care formats. Preserved with Linatural MBS-4 at 2%.
Target pH
4.5 – 5.1
Shelf life (RT · cold)
12–18 mo · 18–24 mo
Final INCI deck (this suspension, ordered by %)
Water, Glycerin, Propanediol, Ethylhexylglycerin, Acetyl Tetrapeptide-5, Benzoic Acid
1
Cosmetic grade
Solid-phase synthesis
COA & SDS
Every single batch
Two carriers
Glycerin or bioferment
Specifications

Everything you need on the technical data sheet.

Peptide INCI
Acetyl Tetrapeptide-5
CAS Number
928006-50-2
Molecular Wt
~492 g/mol (approx.)
Appearance
Clear, colorless aqueous fluid
pH
4.5 – 5.1
Use Rate
1-5% (std)
Add At
Cool-down, ≤ 40 °C
Shelf Life
12–18 mo room temp
18–24 mo refrigerated
Acetyl Tetrapeptide-5 (AT-5) molecular illustration Ac-Val-Tyr-Val-Ala (Diffuporine / aquaporin mimic) · CAS 928006-50-2
The peptide

Acetyl Tetrapeptide-5: Raw Material Overview for Formulators

Information not available in the provided research report regarding Acetyl Tetrapeptide-5's detailed mechanism and specific cosmetic positioning (refer to evidence brief mechanism section). It is primarily positioned for cosmetic leave-on skin care applications.

Market context: Information regarding competitive positioning for Acetyl Tetrapeptide-5 is not available in the provided research report (refer to evidence brief competitor positioning).

Formulate Labs provides Acetyl Tetrapeptide-5 as a convenient 0.1% standard glycerin suspension. This pre-diluted format is engineered for straightforward integration into a diverse array of cosmetic formulations, aiming to ensure consistent performance and streamline manufacturing processes for our partners.

We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the DiffuporineTM-equivalent reference of 0.01% or our 10X lab concentrate at 0.1%.

492
g/mol molecular weight (approx.)
4
4 (acetylated)
2010
commercialised as Diffuporine (Lipotec)
2
carrier options on this page
Ingredient deck assessment

What this material is and isn’t.

Vegan
Synthetic peptide, no animal-derived inputs
Non-GMO
Solid-phase synthesis, not biotech-derived
Cruelty-free
No animal testing in our process
Kosher-suitable
Ingredient deck assessed Kosher-suitable
Halal-suitable
Ingredient deck assessed Halal-suitable
Made & Mixed in USA
US peptide synthesis + US factory

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01
Order placed
You pick a size and quantity. We confirm specs against your formulation if you have one.
02
Robotic production
Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.
03
Batch QC + COA
Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.
Why formulators reach for it

A peptide with a long cosmetic-science track record.

Acetyl Tetrapeptide-5 is the International Nomenclature of Cosmetic Ingredients (INCI) name for this raw material. Formulate Labs consistently uses INCI-first naming and does not market or sell finished products under specific trade names.

Published research

Peer-reviewed literature for due diligence.

Acetyl Tetrapeptide-5 (Diffuporine) is positioned in aquaporin and periorbital cosmetic literature for the appearance of de-puffed, smoother eye contours. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

2021
In vitro
Dermatology

Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts

Kim JH, et al.

Independent fibroblast study evaluating cosmeceutical peptide mixtures including Diffuporine-class sequences for anti-senescence and matrix-support endpoints.

2009
Review
Handbook of Experimental Pharmacology

Skin aquaporins: function in hydration, wound healing, and skin epidermis homeostasis

Hachez C, et al.

Review of aquaporin-3 biology in epidermal water balance, underpinning the cosmetic hydration rationale for Diffuporine-type tetrapeptides.

2009
Review
International Journal of Cosmetic Science

Role of topical peptides in preventing or treating aged skin

Lintner K, et al.

Overview of short biomimetic peptides studied in periorbital and anti-aging cosmetic formulations.

2017
Review
Journal of Cosmetic Dermatology

Cosmeceuticals: peptides, proteins, and growth factors

Lupo MP, et al.

Peer-reviewed context for eye-area cosmetic peptides and structure/function claim boundaries in finished products.

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this suspension.

This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AT-5 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.

Glycerin · 35% Acetyl Tetrapeptide-5 · 0.1% Linaturalâ„¢ MBS-4 · 2% Water · 62.9%
Glycerin
CAS56-81-5
Humectant carrier
35%
Acetyl Tetrapeptide-5
CAS928006-50-2
Active peptide
0.1%
Linatural MBS-4
Multifunctional preservative
2%
Inside Linatural MBS-4
Propanediol
CAS504-63-2
1.7%
Ethylhexylglycerin
CAS70445-33-9
0.2%
Benzoic Acid
CAS65-85-0
0.1%
Water
CAS7732-18-5
Solvent (balance)
62.9%
Formulation guide

Built for chemists who sweat the details.

Typical use rate
Information not available in the provided research report (refer to evidence brief formulation guidance).
Solubility
Information not available in the provided research report (refer to evidence brief formulation guidance).
pH compatibility
Information not available in the provided research report (refer to evidence brief formulation guidance).
Add at
Information not available in the provided research report (refer to evidence brief formulation guidance).
Mixing
Information not available in the provided research report (refer to evidence brief formulation guidance).
Avoid
Information not available in the provided research report (refer to evidence brief formulation guidance).
Pairs well with
Information not available in the provided research report (refer to evidence brief formulation guidance).
Self-preserving
Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs

Documentation

SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.

Need something different?
Custom concentrations, an alternative carrier, allergen-free preservation, COA-on-file, or a regulatory packet for a specific market - reach out and we’ll quote.
Compliance & safety

The fine print, in plain English.

What it’s for
Cosmetic raw material - leave-on hair-care formulations (scalp serums, hair tonics, leave-on hair lotions, density-positioned conditioning treatments) at the use rates above; also acceptable in rinse-off cosmetic products and skincare formats where a peptide-based "supports the look of fuller hair" / scalp-comfort positioning is intended. Not a finished consumer product; not for ingestion, injection, or unsupervised topical use outside a formulated finished product.
Claims guidance
Cosmetic structure / function language only (e.g. supports a less puffy-looking eye area, supports a smoother eye contour). Avoid lymphatic drug language (“treats edema”, “reduces under-eye bags medically”). Do not make therapeutic claims. The peptide is studied in cosmetic in-vitro and panel work; downstream finished-product claims must be substantiated by the brand.
Storage
  • Store between 2-25 °C in original sealed container away from direct light.
  • Cold storage extends shelf life by ~50% relative to room temperature.
  • Once opened, use within the period stated on the COA.
Regulatory
  • INCI: Acetyl Tetrapeptide-5 (per ICID and PCPC dictionary).
  • Not classified as hazardous based on currently available information per OSHA HazCom 2012 / GHS.
  • Compatible with FDA cosmetic regulations and EU 1223/2009 for the intended use.
  • SDS section 16 disclaimer applies; see the per-recipe SDS for the full classification.
Sensitivity
Acetyl Tetrapeptide-5 is generally well-tolerated in cosmetic use at the rates above; the supplier’s HET-CAM and AMES studies on the peptide indicate non-irritating and non-mutagenic behavior at industry-standard concentrations. The peptide is light-sensitive: store and ship in opaque containers, and avoid prolonged exposure to direct sunlight in finished formulations. Avoid prolonged contact with strong oxidisers, sulfuric or phosphoric acids, acetic anhydride, sustained heat above 45 °C, and prolonged exposure to pH > 7.0 - any of these can hydrolyze the peptide and reduce in-formula activity. Patch-test finished formulations per standard cosmetic protocol.
Questions
Documentation, regulatory, custom recipes, COA-on-file requests, or anything else - email materials@formulatelabs.ai and we’ll route to the right person.
1 kg
$56,780.00
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