AT-40 cosmetic peptide suspension · choose base, strength, and preservation
Acetyl Tetrapeptide-40 is a biomimetic soothing peptide found in Telangyn™-class actives, expertly designed to calm reactive skin and visibly reduce redness; Formulate Labs does not sell Telangyn™ or other trademarked SKUs.
Ac-tetrapeptide-40 (Telesomyl / telomere-positioning) · CAS 928006-89-7
Acetyl Tetrapeptide-40 (Ac-Ala-Thr-Asn-Thr) is a biomimetic soothing peptide engineered to suppress the inflammatory cascade triggered by the antimicrobial peptide LL-37. In rosacea-prone, sensitive, and UV-damaged skin, LL-37 is abnormally overexpressed, driving the release of pro-inflammatory interleukins IL-6 and IL-8. By inhibiting these specific mediators, Acetyl Tetrapeptide-40 normalizes the neurovascular response, reduces visible vasodilation (telangiectasia), and mitigates post-inflammatory hyperpigmentation. Furthermore, by limiting this excessive immune response, it prevents the activation of collagen-degrading matrix metalloproteinases (MMPs), preserving skin elasticity. It is optimally positioned for reactive skin, rosacea-care, and post-procedure recovery formulations.
Market context: — Acetyl Tetrapeptide-40 is prominently marketed under the trade name Telangyn™ by Lipotec/Lubrizol, specifically positioned for facial erythema, rosacea relief, and photoprotective soothing. It is frequently benchmarked against other premium barrier-repair peptides, such as Palmitoyl Tripeptide-8 (Neutrazen™) and Palmitoyl Tetrapeptide-7, for sensitive skin and anti-inflammatory applications. Please note that Formulate Labs supplies the unbranded INCI ingredient (Acetyl Tetrapeptide-40) only and does not sell trademarked supplier SKUs.
Formulate Labs offers Acetyl Tetrapeptide-40 in a stable, easily incorporated 0.1% standard glycerin suspension. This ready-to-use format simplifies formulation development, allowing formulators to seamlessly integrate this potent active into diverse cosmetic bases. Our commitment to high purity ensures consistent performance and efficacy for your advanced skincare solutions.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the TelesomylTM-equivalent reference of 0.03% or our 10X lab concentrate at 0.3%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Acetyl Tetrapeptide-40 is the INCI name for the raw material; Formulate Labs does not sell branded or trademarked finished product SKUs.
Acetyl Tetrapeptide-40 (Telesomyl) is positioned in chronological anti-aging literature alongside matrikine and longevity-gene cosmetic peptide research. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Sederma screening study on matrikine-derived peptides modulating longevity-linked pathways and ECM architecture in fibroblast models.
Seminal review of matrikine and signal peptides in chronological anti-aging cosmetic skincare research.
Review of GHK-family gene-modulation and skin-regeneration pathways relevant to Telesomyl chronological-aging cosmetic positioning.
Peer-reviewed overview of advanced anti-aging cosmetic peptides and longevity positioning in leave-on skincare.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AT-40 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
