A potent and selective endogenous agonist for the mu-opiate receptor
Identifies endomorphin-2 as Tyr-Pro-Phe-Phe-NH2. Acetyl Tetrapeptide-15 is the N-acetyl form of that sequence. This paper does not study the cosmetic ingredient.
AT-15 cosmetic peptide suspension · choose base, strength, and preservation
Acetyl Tetrapeptide-15 is the synthetic peptide Ac-Tyr-Pro-Phe-Phe-NH2 (PubChem CID 16657387, CAS 928007-64-1, 613.7 g/mol). It is not Acetyl Dipeptide-1. Formulate Labs supplies it as a cosmetic raw material in aqueous suspension.
Ac-Tyr-Pro-Phe-Phe-NH2 · CAS 928007-64-1
Acetyl Tetrapeptide-15 is a synthetic tetrapeptide. PubChem CID 16657387 records the sequence as Ac-Tyr-Pro-Phe-Phe-NH2, molecular formula C34H39N5O6, molecular weight 613.7 g/mol, and CAS 928007-64-1. The same tetrapeptide sequence without the acetyl group is endomorphin-2, identified by Zadina, Hackler, Ge, and Kastin in Nature in 1997. That paper does not study this acetylated cosmetic ingredient.
Acetyl Tetrapeptide-15 is not Acetyl Dipeptide-1. Calmosensine is a trade name associated with Acetyl Dipeptide-1. Formulate Labs supplies Acetyl Tetrapeptide-15 as a cosmetic raw material in 35% glycerin/water or Sea Kelp Bioferment, at 0.05% or a 0.5% lab concentrate. It is not a drug.
Identity source: PubChem CID 16657387. Sequence context: Zadina et al., Nature, 1997. Confirm the lot against the certificate of analysis.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Acetyl Tetrapeptide-15 refers to the pure INCI material, distinct from proprietary trade-name formulations that may contain this peptide alongside other ingredients.
Acetyl Tetrapeptide-15 is Ac-Tyr-Pro-Phe-Phe-NH2 (PubChem CID 16657387). That sequence, without the acetyl group, is endomorphin-2, described by Zadina and colleagues in Nature in 1997. The papers below are related peptide literature. They are not proof of a finished-product effect for this suspension. Acetyl Tetrapeptide-15 is not Calmosensine. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Identifies endomorphin-2 as Tyr-Pro-Phe-Phe-NH2. Acetyl Tetrapeptide-15 is the N-acetyl form of that sequence. This paper does not study the cosmetic ingredient.
Review of synthetic peptides used in sensitive-skin cosmetics. It is not a chemical-identity record for Acetyl Tetrapeptide-15.
Conformational study of mu-opioid peptides. Endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) is a related sequence; this paper is not a study of the acetylated cosmetic ingredient.
Overview of calming and anti-inflammatory signal peptides in sensitive-skin leave-on cosmetic products.
Peer-reviewed context for sensitive-skin cosmetic peptides and structure/function claim boundaries.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AT-15 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.