AT-15 cosmetic peptide suspension · choose base, strength, and preservation
Acetyl Tetrapeptide-15 is a soothing peptide found in Skinasensyl™ and Pep®-Sensyl class actives, meticulously engineered to minimize neurogenic inflammation and raise the skin's tolerance threshold against environmental stressors (Formulate Labs does not sell branded trade names).
Ac-Ser-Asp-Gly-Met (Calmosensine / opioid mimic) · CAS 928006-88-6
Acetyl Tetrapeptide-15 is a sophisticated synthetic peptide designed to act as a neurocosmetic soothing agent. It functions by selectively binding to μ-opioid receptors on cutaneous sensory nerve endings, which inhibits adenylate cyclase phosphorylation and transient receptor potential vanilloid 1 (TRPV1) pathway activation. This cascade prevents the release of pro-inflammatory neuromediators like CGRP, effectively raising the skin’s tolerance threshold against thermal and environmental stressors. Cosmetically, Acetyl Tetrapeptide-15 is ideally positioned for sensitive, hyper-reactive, and post-procedure skincare concepts where mitigating neurogenic inflammation is a primary formulation objective.
Market context: — The landscape for neuro-soothing peptides includes established trade names such as Skinasensyl™ from BASF, marketed for hyper-reactive skin, and Pep®-Sensyl, positioned for allergy-prone profiles. Formulate Labs distinguishes itself by providing Acetyl Tetrapeptide-15 as a pure INCI material, suspended in custom carriers. This approach offers formulators unparalleled flexibility and cost-effectiveness, moving beyond proprietary branded solutions to empower innovation.
Formulate Labs offers Acetyl Tetrapeptide-15 in a range of high-quality suspension carriers, including standard Glycerin/Water and nourishing Sea Kelp Bioferment. Our commitment is to provide the pure INCI in custom, unbranded carriers, ensuring maximum formulation flexibility and bypassing the constraints of proprietary trade-name SKUs. This allows formulators to integrate Acetyl Tetrapeptide-15 effectively across diverse cosmetic applications, optimizing product performance and market positioning.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the CalmosensineTM-equivalent reference of 0.01% or our 10X lab concentrate at 0.1%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Acetyl Tetrapeptide-15 refers to the pure INCI material, distinct from proprietary trade-name formulations that may contain this peptide alongside other ingredients.
Acetyl Tetrapeptide-15 (Calmosensine) is an opioid-mimetic tetrapeptide cited in sensitive-skin cosmetic literature for soothed, comfortable-looking skin. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Dedicated review of synthetic peptides for sensitive-skin cosmetics, covering Calmosensine-class opioid-mimetic calming sequences.
Structural characterization of mu-opioid receptor peptide conformations, providing mechanistic context for Calmosensine-type cosmetic comfort peptides.
Overview of calming and anti-inflammatory signal peptides in sensitive-skin leave-on cosmetic products.
Peer-reviewed context for sensitive-skin cosmetic peptides and structure/function claim boundaries.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AT-15 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
