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Peptide · Aqueous Suspension · Cosmetic Grade

Acetyl Tetrapeptide-15

AT-15 cosmetic peptide suspension · choose base, strength, and preservation

Acetyl Tetrapeptide-15 is the synthetic peptide Ac-Tyr-Pro-Phe-Phe-NH2 (PubChem CID 16657387, CAS 928007-64-1, 613.7 g/mol). It is not Acetyl Dipeptide-1. Formulate Labs supplies it as a cosmetic raw material in aqueous suspension.

  • Two bases, two strengths, four preservation options - 10 recipes total, all made-to-order
  • Cosmetic-grade Acetyl Tetrapeptide-15 · CAS 928007-64-1 · MW 613.7 g/mol
  • COA + SDS + TDS included with every batch · cold-chain optional on request
Base: Glycerin Suspension
Carrier: our single-origin Sea Kelp Bioferment. View material
Strength: 0.05% AT-15
Preservation: Linatural™ MBS-4 INCI breakdown
35% glycerin in water. Selectable preservative; broadest compatibility across personal-care formats. Preserved with Linatural™ MBS-4 at 2%.
Target pH
4.5 – 5.1
Shelf life (RT · cold)
12–18 mo · 18–24 mo
Final INCI deck (this suspension, ordered by %)
Water, Glycerin, Propanediol, Ethylhexylglycerin, Benzoic Acid, Acetyl Tetrapeptide-15
1
Cosmetic grade
Solid-phase synthesis
COA & SDS
Every single batch
Two carriers
Glycerin or bioferment
Specifications

Everything you need on the technical data sheet.

Peptide INCI
Acetyl Tetrapeptide-15
CAS Number
928007-64-1
Molecular Wt
613.7 g/mol
Appearance
Clear, colorless aqueous fluid
pH
4.5 – 5.1
Use Rate
1%-3% (1X)
Add At
Cool-down, ≤ 40 °C
Shelf Life
12–18 mo room temp
18–24 mo refrigerated
Acetyl Tetrapeptide-15 illustration Ac-Tyr-Pro-Phe-Phe-NH2 · CAS 928007-64-1
The peptide

Acetyl Tetrapeptide-15

Acetyl Tetrapeptide-15 is a synthetic tetrapeptide. PubChem CID 16657387 records the sequence as Ac-Tyr-Pro-Phe-Phe-NH2, molecular formula C34H39N5O6, molecular weight 613.7 g/mol, and CAS 928007-64-1. The same tetrapeptide sequence without the acetyl group is endomorphin-2, identified by Zadina, Hackler, Ge, and Kastin in Nature in 1997. That paper does not study this acetylated cosmetic ingredient.

Acetyl Tetrapeptide-15 is not Acetyl Dipeptide-1. Calmosensine is a trade name associated with Acetyl Dipeptide-1. Formulate Labs supplies Acetyl Tetrapeptide-15 as a cosmetic raw material in 35% glycerin/water or Sea Kelp Bioferment, at 0.05% or a 0.5% lab concentrate. It is not a drug.

Identity source: PubChem CID 16657387. Sequence context: Zadina et al., Nature, 1997. Confirm the lot against the certificate of analysis.

613.7
g/mol (PubChem CID 16657387)
4
residues, Ac-Tyr-Pro-Phe-Phe-NH2
C34
H39N5O6
2
carrier options on this page
Ingredient deck assessment

What this material is and isn’t.

Vegan
Synthetic peptide, no animal-derived inputs
Non-GMO
Solid-phase synthesis, not biotech-derived
Cruelty-free
No animal testing in our process
Kosher-suitable
Ingredient deck assessed Kosher-suitable
Halal-suitable
Ingredient deck assessed Halal-suitable
Made & Mixed in USA
US peptide synthesis + US factory

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01
Order placed
You pick a size and quantity. We confirm specs against your formulation if you have one.
02
Robotic production
Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.
03
Batch QC + COA
Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.
Why formulators reach for it

A peptide with a long cosmetic-science track record.

Recorded tetrapeptide identity
PubChem CID 16657387 lists Acetyl Tetrapeptide-15 as Ac-Tyr-Pro-Phe-Phe-NH2, CAS 928007-64-1, formula C34H39N5O6, 613.7 g/mol.
Not Acetyl Dipeptide-1
Calmosensine is a trade name associated with Acetyl Dipeptide-1, a different peptide. Do not use that name for this material.
Supplied as a suspension
Aqueous glycerin/water or Sea Kelp Bioferment, at the strengths listed on this page.
Cosmetic raw material
For formulation into finished topical products. It is not a drug. Finished-product claims have to be substantiated by the brand.

Acetyl Tetrapeptide-15 refers to the pure INCI material, distinct from proprietary trade-name formulations that may contain this peptide alongside other ingredients.

Published research

Peer-reviewed literature for due diligence.

Acetyl Tetrapeptide-15 is Ac-Tyr-Pro-Phe-Phe-NH2 (PubChem CID 16657387). That sequence, without the acetyl group, is endomorphin-2, described by Zadina and colleagues in Nature in 1997. The papers below are related peptide literature. They are not proof of a finished-product effect for this suspension. Acetyl Tetrapeptide-15 is not Calmosensine. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

1997
Primary paper
Nature

A potent and selective endogenous agonist for the mu-opiate receptor

Zadina JE, Hackler L, Ge LJ, Kastin AJ

Identifies endomorphin-2 as Tyr-Pro-Phe-Phe-NH2. Acetyl Tetrapeptide-15 is the N-acetyl form of that sequence. This paper does not study the cosmetic ingredient.

2021
Review
Pharmaceuticals

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin

Pinto JR, et al.

Review of synthetic peptides used in sensitive-skin cosmetics. It is not a chemical-identity record for Acetyl Tetrapeptide-15.

2020
Mechanism
Biophysical Journal

Low Energy Conformations for Endogenous Mu-Receptor-Specific Peptides

Nielsen SV, et al.

Conformational study of mu-opioid peptides. Endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) is a related sequence; this paper is not a study of the acetylated cosmetic ingredient.

2009
Review
International Journal of Cosmetic Science

Role of topical peptides in preventing or treating aged skin

Lintner K, et al.

Overview of calming and anti-inflammatory signal peptides in sensitive-skin leave-on cosmetic products.

2017
Review
Journal of Cosmetic Dermatology

Cosmeceuticals: peptides, proteins, and growth factors

Lupo MP, et al.

Peer-reviewed context for sensitive-skin cosmetic peptides and structure/function claim boundaries.

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this suspension.

This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AT-15 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.

Glycerin · 35% Acetyl Tetrapeptide-15 · 0.05% Linatural™ MBS-4 · 2% Water · 62.95%
Glycerin
CAS56-81-5
Humectant carrier
35%
Acetyl Tetrapeptide-15
CAS928007-64-1
Active peptide
0.05%
Linatural™ MBS-4
Multifunctional preservative
2%
Inside Linatural™ MBS-4
Propanediol
CAS504-63-2
1.7%
Ethylhexylglycerin
CAS70445-33-9
0.2%
Benzoic Acid
CAS65-85-0
0.1%
Water
CAS7732-18-5
Solvent (balance)
62.95%
Formulation guide

Built for chemists who sweat the details.

Typical use rate
1%–3% of the 0.05% (1X) suspension (industry recommended); 0.1%–0.3% of the 0.5% (10X) lab concentrate for the same in-formula peptide level of approximately 0.0005% – 0.0015%
Solubility
Highly water-soluble
pH compatibility
pH 4.0–8.0
Add at
Final cooling phase, below 40°C
Mixing
Add slowly with gentle agitation during the final cooling phase.
Avoid
Temperatures above 40°C; advised to monitor potential protease/enzyme interactions with Sea Kelp Bioferment.
Pairs well with
Self-preserving
Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs

Documentation

SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.

Need something different?
Custom concentrations, an alternative carrier, allergen-free preservation, COA-on-file, or a regulatory packet for a specific market - reach out and we’ll quote.
Compliance & safety

The fine print, in plain English.

What it’s for
Cosmetic raw material - leave-on hair-care formulations (scalp serums, hair tonics, leave-on hair lotions, density-positioned conditioning treatments) at the use rates above; also acceptable in rinse-off cosmetic products and skincare formats where a peptide-based "supports the look of fuller hair" / scalp-comfort positioning is intended. Not a finished consumer product; not for ingestion, injection, or unsupervised topical use outside a formulated finished product.
Claims guidance
Cosmetic structure / function language only (e.g. supports a soothed-looking finish, supports a more comfortable appearance). Avoid opioid drug language (“blocks pain”, “analgesic”, “treats sensitivity”). Do not make therapeutic claims. The peptide is studied in cosmetic in-vitro and panel work; downstream finished-product claims must be substantiated by the brand.
Storage
  • Store between 2-25 °C in original sealed container away from direct light.
  • Cold storage extends shelf life by ~50% relative to room temperature.
  • Once opened, use within the period stated on the COA.
Regulatory
  • INCI: Acetyl Tetrapeptide-15 (per ICID and PCPC dictionary).
  • Not classified as hazardous based on currently available information per OSHA HazCom 2012 / GHS.
  • Compatible with FDA cosmetic regulations and EU 1223/2009 for the intended use.
  • SDS section 16 disclaimer applies; see the per-recipe SDS for the full classification.
Sensitivity
Acetyl Tetrapeptide-15 is generally well-tolerated in cosmetic use at the rates above; the supplier’s HET-CAM and AMES studies on the peptide indicate non-irritating and non-mutagenic behavior at industry-standard concentrations. The peptide is light-sensitive: store and ship in opaque containers, and avoid prolonged exposure to direct sunlight in finished formulations. Avoid prolonged contact with strong oxidisers, sulfuric or phosphoric acids, acetic anhydride, sustained heat above 45 °C, and prolonged exposure to pH > 7.0 - any of these can hydrolyze the peptide and reduce in-formula activity. Patch-test finished formulations per standard cosmetic protocol.
Questions
Documentation, regulatory, custom recipes, COA-on-file requests, or anything else - email materials@formulatelabs.ai and we’ll route to the right person.
1 kg
$325.00
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