AO-3 cosmetic peptide suspension · choose base, strength, and preservation
Acetyl Octapeptide-3 is the advanced neuro-peptide found in Snap-8-class actives, expertly formulated to attenuate dynamic muscle contractions and visibly reduce expression lines; Formulate Labs supplies Acetyl Octapeptide-3 only — we do not sell or represent Snap-8.
Ac-Glu-Met-Gln-Arg-Arg-Ala-Asp-Ala (Snap-8 / extended Argireline) · CAS 868149-19-5
Acetyl Octapeptide-3, an eight-amino-acid derivative of Acetyl Hexapeptide-8, functions as a topical neuromodulator by mimicking the N-terminal end of the SNAP-25 protein. It competitively inhibits the SNARE complex, thereby attenuating the exocytosis of acetylcholine at the neuromuscular junction and reducing dynamic muscle contractions. The cosmetic industry positions Acetyl Octapeptide-3 as a premium, non-invasive “Botox-like” neuro-peptide, especially effective for minimizing facial expression lines in regions such as the periorbital and glabellar areas.
Market context: Acetyl Octapeptide-3 competes in the premium anti-aging segment, often referenced alongside supplier-branded actives such as Lipotec’s SNAP-8™, which it is a derivative of, showing a 30% structural efficacy upgrade. Other advanced iterations include hexapeptides like Argireline® Amplified and Spec Chem’s SpecPed® AO3P, all positioned for needle-free expression line reduction. Formulate Labs supplies Acetyl Octapeptide-3 as a pure INCI ingredient and does not sell or distribute any supplier-branded trade-name SKUs.
Formulate Labs provides Acetyl Octapeptide-3 in expertly prepared suspension carriers, including our standard Glycerin/Water solutions and nourishing Sea Kelp Bioferment. These carriers ensure optimal stability and ease of integration into diverse formulations, available in typical active concentrations of 0.05% or as lab concentrates of 1% active ingredient.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the Snap-8TM-equivalent reference of 0.05% or our 10X lab concentrate at 0.5%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Formulate Labs supplies Acetyl Octapeptide-3 only; trade names like Snap-8 refer to supplier-branded actives that we do not sell or represent.
Acetyl Octapeptide-3 (Snap-8) is an extended Argireline-class octapeptide with published SNARE-pathway mechanism and expression-line clinical literature. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Foundational Lipotec paper on the SNAP-25-mimetic sequence family that Snap-8 extends; describes SNARE-complex interference and pilot wrinkle-reduction panels.
Randomized, placebo-controlled Argireline-class study reporting significant peri-orbital wrinkle improvement; useful clinical benchmark for Snap-8 positioning.
Compares Argireline and structural analogues for skin permeation and SNARE-pathway activity, relevant to extended octapeptide expression-line design.
Peer-reviewed overview of neurotransmitter-inhibitor cosmetic peptides including Argireline-class sequences and published efficacy context.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AO-3 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
