Acetyl Octapeptide-3

Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 · CAS 868844-74-0

The peptide

Acetyl Octapeptide-3 is a synthetic eight-residue peptide. PubChem CID 76283482 records the sequence as Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, molecular formula C41H70N16O16S, molecular weight 1,075.2 g/mol, and CAS 868844-74-0.

Formulate Labs supplies Acetyl Octapeptide-3 as a cosmetic raw material for finished topical products. It is sold here as an aqueous suspension in 35% glycerin/water or Sea Kelp Bioferment, at 0.05% or a 0.5% lab concentrate. It is not a drug. Published studies of the shorter peptide Acetyl Hexapeptide-8 are studies of a different molecule.

Identity source: PubChem CID 76283482. Confirm the lot against the certificate of analysis.

1,075.2

g/mol (PubChem CID 76283482)

8

amino-acid residues, N-acetyl, C-amide

C41

H70N16O16S

2

carrier options on this page

Ingredient deck assessment

What this material is and isn’t.

Vegan

Synthetic peptide, no animal-derived inputs

Non-GMO

Solid-phase synthesis, not biotech-derived

Cruelty-free

No animal testing in our process

Kosher-suitable

Ingredient deck assessed Kosher-suitable

Halal-suitable

Ingredient deck assessed Halal-suitable

Made & Mixed in USA

US peptide synthesis + US factory

These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.

Made to Order

Built fresh on our robotic platform.

Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.

01

Order placed

You pick a size and quantity. We confirm specs against your formulation if you have one.

02

Robotic production

Your inputs go in. We process, blend, and fill sealed packaging - all inside our AI-powered robotic factory.

03

Batch QC + COA

Every batch is tested for actives, pH, micro, and appearance. A batch-specific COA, SDS, and TDS ship with the order.

Why formulators reach for it

A peptide with a long cosmetic-science track record.

Recorded octapeptide identity

PubChem CID 76283482 lists Acetyl Octapeptide-3 as Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, CAS 868844-74-0, formula C41H70N16O16S, 1,075.2 g/mol.

Supplied as a suspension

Aqueous glycerin/water or Sea Kelp Bioferment, at the strengths listed on this page.

Cosmetic raw material

For formulation into finished topical products. It is not a drug. Finished-product claims have to be substantiated by the brand.

Not the hexapeptide

Acetyl Hexapeptide-8 is a six-residue peptide. Published results on that hexapeptide are not results for this octapeptide.

Formulate Labs supplies Acetyl Octapeptide-3 only; trade names like Snap-8 refer to supplier-branded actives that we do not sell or represent.

Published research

Peer-reviewed literature for due diligence.

The papers below are published work on related acetyl-hexapeptide ingredients. They are not clinical studies of Acetyl Octapeptide-3 unless the title says so. Chemical identity for this ingredient is PubChem CID 76283482. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.

4 curated references

Mechanism, clinical, in-vitro, and review literature

2002

Mechanism

International Journal of Cosmetic Science

A synthetic hexapeptide (Argireline) with antiwrinkle activity

Blanes-Mira C, et al.

Paper on the hexapeptide acetyl hexapeptide-3 (Argireline), not on Acetyl Octapeptide-3. Included only as related published work on a shorter peptide.

DOI PubMed

2013

Clinical trial

American Journal of Clinical Dermatology

The anti-wrinkle efficacy of Argireline, a synthetic hexapeptide, in Chinese subjects

Wang Y, et al.

Clinical paper on Argireline (acetyl hexapeptide), not on Acetyl Octapeptide-3.

DOI PubMed

2018

In vitro

Scientific Reports

Enhanced skin permeation of anti-wrinkle peptides via molecular modification

Lim SH, et al.

Permeation study of anti-wrinkle peptides. Read the paper for which sequences were actually tested before applying it to Acetyl Octapeptide-3.

DOI PubMed

2017

Review

Journal of Cosmetic Dermatology

Cosmeceuticals: peptides, proteins, and growth factors

Lupo MP, et al.

Review of cosmetic peptides, proteins, and growth factors. Not an Acetyl Octapeptide-3 monograph.

DOI PubMed

These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.

Composition

What’s in this suspension.

This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AO-3 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.

Glycerin · 35% Acetyl Octapeptide-3 · 0.05% Linatural™ MBS-4 · 2% Water · 62.95%

Glycerin

CAS56-81-5

Humectant carrier

35%

Acetyl Octapeptide-3

CAS868844-74-0

Active peptide

0.05%

Linatural^™ MBS-4

Multifunctional preservative

2%

Inside Linatural^™ MBS-4

Propanediol

CAS504-63-2

1.7%

Ethylhexylglycerin

CAS70445-33-9

0.2%

Benzoic Acid

CAS65-85-0

0.1%

Water

CAS7732-18-5

Solvent (balance)

62.95%

Formulation guide

Built for chemists who sweat the details.

Typical use rate

3%–10% of the 0.05% (1X) suspension (industry recommended); 0.3%–1% of the 0.5% (10X) lab concentrate for the same in-formula peptide level of approximately 0.0015% – 0.005%

Solubility

Highly water-soluble; easily incorporated into aqueous phases and our stock carriers (Glycerin/Water suspensions, Sea Kelp Bioferment).

pH compatibility

Stable within a pH range of 3.0 to 7.0, with 5.0–7.0 recommended for optimal peptide integrity and skin barrier compatibility.

Add at

During the cool-down phase below 40°C.

Mixing

Easily incorporated into aqueous phases.

Avoid

Strong oxidizing agents, highly active proteolytic enzymes, direct UV exposure, and temperatures above 40°C.

Pairs well with

Pairs well with other neuromodulating peptides like Acetyl Hexapeptide-8 and is structurally stable in bioferments such as Sea Kelp.

Self-preserving

Yes - 2% Linatural MBS-4. Boost preservation per your finished-formula needs

Documentation

SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.

Safety Data Sheet (SDS)

16-section GHS · Rev. 0.1 · per-recipe

Technical Data Sheet (TDS)

Composition, attributes, formulation guidance · Rev. 0.1

Need something different?

Custom concentrations, an alternative carrier, allergen-free preservation, COA-on-file, or a regulatory packet for a specific market - reach out and we’ll quote.

Compliance & safety

The fine print, in plain English.

What it’s for

Cosmetic raw material - leave-on hair-care formulations (scalp serums, hair tonics, leave-on hair lotions, density-positioned conditioning treatments) at the use rates above; also acceptable in rinse-off cosmetic products and skincare formats where a peptide-based "supports the look of fuller hair" / scalp-comfort positioning is intended. Not a finished consumer product; not for ingestion, injection, or unsupervised topical use outside a formulated finished product.

Claims guidance

Cosmetic structure / function language only (e.g. softens the look of expression lines, supports a smoother-looking finish). Avoid neuromodulator drug language (“botox alternative”, “paralyzes muscles”, “blocks nerve signals”). Do not make therapeutic claims. The peptide is studied in cosmetic in-vitro and panel work; downstream finished-product claims must be substantiated by the brand.

Storage

Store between 2-25 °C in original sealed container away from direct light.
Cold storage extends shelf life by ~50% relative to room temperature.
Once opened, use within the period stated on the COA.

Regulatory

INCI: Acetyl Octapeptide-3 (per ICID and PCPC dictionary).
Not classified as hazardous based on currently available information per OSHA HazCom 2012 / GHS.
Compatible with FDA cosmetic regulations and EU 1223/2009 for the intended use.
SDS section 16 disclaimer applies; see the per-recipe SDS for the full classification.

Sensitivity

Acetyl Octapeptide-3 is generally well-tolerated in cosmetic use at the rates above; the supplier’s HET-CAM and AMES studies on the peptide indicate non-irritating and non-mutagenic behavior at industry-standard concentrations. The peptide is light-sensitive: store and ship in opaque containers, and avoid prolonged exposure to direct sunlight in finished formulations. Avoid prolonged contact with strong oxidisers, sulfuric or phosphoric acids, acetic anhydride, sustained heat above 45 °C, and prolonged exposure to pH > 7.0 - any of these can hydrolyze the peptide and reduce in-formula activity. Patch-test finished formulations per standard cosmetic protocol.

Questions

Documentation, regulatory, custom recipes, COA-on-file requests, or anything else - email materials@formulatelabs.ai and we’ll route to the right person.

Something Exciting is Coming

Acetyl Octapeptide-3

Everything you need on the technical data sheet.