AH-49 cosmetic peptide suspension · choose base, strength, and preservation
Acetyl Hexapeptide-49 is a bioactive, anti-inflammatory peptide found in Delisens™-class and SpecPed®-class actives (Formulate Labs does not sell these trade names), designed to rapidly soothe sensitive skin and mitigate neurogenic inflammation.
Ac-hexapeptide-49 (peroxiredoxin-mimetic) · CAS 1477324-81-8
Acetyl Hexapeptide-49 is a sophisticated synthetic peptide engineered to address skin sensitivity at its core. It operates by down-regulating Protease-Activated Receptor 2 (PAR-2) activity in epidermal keratinocytes, a key pathway in skin inflammation. By intercepting the release of pro-inflammatory interleukins (IL-6, IL-8) and calcitonin gene-related peptide (CGRP), Acetyl Hexapeptide-49 effectively mitigates neurogenic inflammation. Cosmetically, it is positioned as a high-performance soothing agent for sensitive, reactive, and rosacea-prone skin, designed to rapidly alleviate pruritus, reduce trans-epidermal water loss (TEWL), and restore barrier integrity.
Market context: Acetyl Hexapeptide-49 is recognized for its unique mechanism of action, often compared to market leaders such as Delisens™ (Lubrizol / Lipotec), which focuses on alleviating discomfort and restoring physiological tolerance, and SpecPed® AH49 (Spec-Chem Industry), known for inhibiting inflammatory factors and improving cell proliferation. It is critical to note that Formulate Labs exclusively supplies the pure INCI designation Acetyl Hexapeptide-49 and does not sell, carry, or represent these aforementioned trade-name SKUs.
At Formulate Labs, we offer Acetyl Hexapeptide-49 in high-quality Glycerin/Water suspensions and Sea Kelp Bioferment carriers. Its excellent water solubility ensures seamless integration into your formulations, providing a reliable and potent active that upholds our commitment to delivering superior cosmetic raw materials.
We supply it as a finished aqueous suspension in two carriers - a 35% glycerin / water base for maximum formulation flexibility, or dosed directly into our single-origin Sea Kelp Bioferment. Both ship at the supplier reference of 0.001% or our 10X lab concentrate at 0.01%.
These attributes are assessments based on the ingredient deck and the supplier information available to us. They are not third-party certifications (no Kosher, Halal, Vegan, or similar certifying body has audited or issued a certificate for this material). If your finished product requires a specific certified status, please reach out and we’ll walk through what we can document.
Every lot is produced to order in our AI-powered robotic factory. Nothing sits on a warehouse shelf going stale - you get a date-of-manufacture-fresh batch every time.
Formulate Labs exclusively supplies the pure INCI designation Acetyl Hexapeptide-49 and does not sell, carry, or represent any trade-name SKUs mentioned for market context.
Acetyl Hexapeptide-49 is positioned in sensitive-skin and barrier-support cosmetic literature as a peroxiredoxin-mimetic resilience peptide. These are independent, third-party papers we link for formulators evaluating mechanism, tolerability, and published panel data. We did not conduct this research and do not guarantee replication in your finished formula.
Review of synthetic peptides for sensitive and reactive skin types, including barrier-support hexapeptide sequences in the AH-49 class.
Overview of antioxidant- and resilience-positioned signal peptides in sensitive-skin anti-aging formulas.
Clinical review of peptide cosmeceuticals for sensitive skin covering barrier support mechanisms and evidence review practices.
Peer-reviewed summary of calming and barrier-positioned cosmetic peptides and published tolerability context.
These citations are provided for informational and formulation-research purposes only. Study designs, concentrations, vehicle systems, and populations vary and may not match the suspensions on this page. Published results do not constitute FDA or EU cosmetic claim substantiation for your brand. Always review the primary literature and consult your regulatory counsel before making structure/function statements on finished products.
This is the per-ingredient composition of the suspension as it ships. Updates dynamically when you change the base, strength, or preservation system above. The peptide line shows the AH-49 loading; the preservative line shows the supplier-blend percentage with its sub-ingredients nested below.
SDS + TDS are issued per recipe (each base / preservative combination has its own regulatory paperwork). The links below swap when you change your selection above. COA is batch-specific and ships with the order.
